Super fungus erupts in beautiful much ground, call " super " antibiotic!

Super fungus is raided once more?

On April 8, liao Moqing of professor of dermatology of hospital of long march of academician of Chinese Academy of Engineering, the 2nd Military Medical University is right " Chinese news weekly " express, up to now, china already affirmed bacterium of 18 ear beads is clinical infection case of illness.

Message, come back to cause the wide attention of public opinion namely.

According to Introduction Liao Moqing, up to 2017, the whole world has 24 countries to had appeared the outbreak of ear beads bacterium the gender is popular, include the country such as Japan, United States, England, Spain, India.

Will ear beads bacterium raid?

Newest menace comes from the United States.

Current, american disease control and precautionary center (CDC) already included ear beads mushroom " urgent menace " list. Newest bulletin indicates its official net, up to by Feburary 2019, the United States affirmed 587 case of illness in all, among them 309 are in new York city, the of nearly 50% person in the person that affect dies inside 90 days.

As we have learned, because ear beads bacterium is in patient ear depart comes out for the first time, if the beads bacterium like Buddha bead is belonged to,attribute spore figure, so bacterium of entitle ear beads.

It is species of fungus of a kind of when Japan discovered 2009 new cause of disease, because its are had multiple be able to bear or endure the feature with medicine and deadly high rate, also be called " super fungus " .

According to the view of CDC, the symptom of ear beads bacterium may detect hard, because the patient often has fallen ill, only the lab checks OK identifying. Ear beads bacterium can cause the infection of different type, include blood stream to affect, hurt an infection and ear ministry infection. Had accepted an operation recently, live in sanatorium or the breathing tube, person that feeds conduit of esophagus or central vein appears the risk is highest.

"According to the information of limited amount patient, the person that the ear beads bacterium of 30%~60% is affected has died. But, among them a lot of people contract other and severe disease, this also increased the risk that they die. " CDC expresses.

Although fungus affects great majority to be able to medication through fighting fungus, but report according to new York Times, the case of illness of infection of ear beads bacterium of more than 90% is opposite at least one kind to fight fungus medicaments basically to be able to bear or endure suffer, the 30% medicaments that reach two kinds of above to two kinds are able to bear or endure suffer.

The characteristic of ear beads bacterium is to be able to be in dry go up with damp surface, bedding, floor, cistern, air, bed, the different environment such as the in-house organization of the skin, nasal cavity and patient survives for long. Once discover ear beads bacterium, answer to adopt osculatory precautionary measures instantly.

What what I hope is, this kind of fungus is current and main inside consist in hospital, depart is mixed from clinical specimen about the implements that is polluted by its. Accordingly, resembling division of ICU ward, blood, tumor division waiting is tall danger section office.

Had not discovered ear beads bacterium inside community at present, but its immature to having growth of system of immune blemish, immunity person is deadly, include a new student, the old person, person that smoke, diabetic and the person that have disease of oneself immunity system.

Regretful is, this kind of super fungus still does not understand specific origin at present. Researcher thinks, this is recently evolution comes out, the new species that gets used to ability of environment of human body host quickly, basically cause haemal infection, deadly rate is as high as 60% .

Nevertheless Professor Liao Moqing also expresses, from at present the result that monitor looks, bacterium of beads of Chinese occurrence ear erupts the possibility of sexual popularity is inferior.

Amount to the introduction according to Liu Wei of director of division of fungus of skin of Chinese academy of medical sciences, these 18 are the data that chinese mainland has scientific research article to publish account up to now, specific it is Beijing 3, shenyang 15.

Nevertheless, capital market already was churned.

On April 10, concept of many super fungus dish in rise abruptly, industry of drug of medicine of industry of beautiful drug of biology of industry of couplet annulus drug, 4 annulus, Lai, Lu Kang, Hai Xiang in succession harden.

Super bacterium earnestly needs new-style antibiotic

Ear beads bacterium is merely in recent years one of the new species of microbial evolution. Before this, more the one word with hep masses is " super bacterium " .

Super bacterium is not to refer in particular to some to plant bacterium, however a variety of those pairs of antibiotic have be used in a general sense be able to bear or endure the bacterium of property of a medicine, but World Health Organization (WHO) ever had undertaken more accurate enumerate to this kind of bacterium.

In Feburary 2017, WHO released first key pathogen detailed list that is badly in need of new-style antibiotic, aim to coach and promote the research of new-style antibiotic and development, 12 kinds of bacteria are phyletic take one's place in the ranks this detailed list.

This detailed list is cent of 12 kinds of bacteria 3 categories: Dangerous, Gao Hezhong (Critical, high, medium) .

"Critical " the category includes 3 kinds of bacteria: Bowman does not use bacillus, green pus bacili and bacterium of alvine bacili division. These 3 kinds of bacteria already arose to be able to bear or endure to a variety of antibiotic property of a medicine, include antibiotic of Xi of carbolic green mildew, and antibiotic of Xi of carbolic green mildew is to become what the ability when all other treat failure can use only " final step " .

These 3 kinds of bacteria can cause a series of serious infection, include pneumonic, meningitis, bacterium, dysenteric wait for a disease.

"High " and " Medium " the nine other pathogen of the category is the bacterium that causes commonner disease. These diseases also may be deadly, and defy give birth to element be able to bear or endure property of a medicine increases increasingly. In detailed list, cause clap drench the bacterium such as coccus and the salmonella that cause bromatoxism also because be able to bear or endure,property of a medicine is brought into to attribute need research and development the bacterium of new-style antibiotic.

Antibiotic treats Shi Shangceng take credit to oneself in human disease to Wei.

From 1928 Fulaiming discovers British scientist after penicillin, scientists discovered a lot of medicaments that can control the microbial infection such as bacterium and virus in succession, a general designation is antibiotic.

The ceaseless discovery of antibiotic reachs wide application, for open up of human conquer contagion road; But be opposite ever since antibiotic is frequent and unessential is used make be able to bear or endure medical bacterium namely so called super bacterium appears.

The Marie-Paule Kieny of assistant total a secretary in charge of sth that WHO is in charge of wholesome system and innovation general affairs expresses when afore-mentioned detailed list release: "Not be to want to use person of new super bacteria gally, but released a signal to researcher and pharmacy company however, this is them should preferential settlement issue. This is them should preferential settlement issue..

Market research and development is waited for drive

However, initiative market action can not let people heart wish along with place.

In July 2018, nuo China announces to stop the inchoate research and development of content of bane of antibiotic, disease-resistant. Before this, asilikang also offerred antibiotic remedy to brightness luck, indication medicine look forward to is not fond of antibiotic business what expect in that way like people.

A group of data that WHO releases also confirmed the difficult position of antibiotic research and development from flank.

According to statistic, 20 centuries since 80 time, the new antibiotic measure that FDA approves is in all the time drop: 1983-1987 year, 16 kinds of new drug win American FDA approval; 1988-1992 year drop reach 14; 1993-1997 year drop reach 10; 2003-2007 year have 5 only; 1996-2000, only 6 kinds of antibiotic come out.

Predestined relationship how about this?

Without exception because of economic interest. The research data of healthy policy center shows Ge Lisi of horse of Du Ke university, obtain antibiotic of approved 16 kinds of brands to plant to 2017 from 2000, only year of 5 kinds sale can exceed 100 million dollar; And new-style anticarcinogen the sale of content criterion at every turn billions of dollar, difference wide gap.

Kieny also admits, on current market, antibiotic is not a charming investment. If use proper, these medicaments need very short time to be able to be opposite only disease be successful, so they won't bring tall redound in that way like the medicaments that treats chronic disease.

So, kieny expresses, if rely on market strength to solve a problem merely, we are the most pressing the new-style antibiotic of need will cannot get seasonable research and development; So government and wholesome orgnaization need strengthen cooperation, expand to develop the opportunity of these medicaments in time thereby.

Situation already austere. According to WHO statistic, annual the whole world makes an appointment with 700 thousand person to die at all sorts of is able to bear or endure medical bacterium infection, 230 thousand new student die young accordingly.

Kieny expresses, the one part of the solution is to find new method to reward the pharmacy company that develops these antibiotic. A kind of idea is the early days charge that agrees to pay pharmacy the company, perhaps only should new pharmaceuticals appears in the market, use carefully according to guidelines, have money reward to these pharmacy companies.

The United States already took action.

July 2012, the United States was passed " urge development antibiotic proposed law " . According to the regulation, the antibiotic medicaments that accords with a standard will be obtained additional patent protection of 5 years period, make patent is protected thereby period time limit is as long as 10 years, in order to help developer disinvestment.

In the meantime, advanced research and development management board established institute of American nation health and biology medicine to defy antibiotic is able to bear or endure accelerator of pharmacy of medical bacterium biology (CARB-X) , offer allocate funds use at supporting antibiotic medicaments to discover a project.

"Be restricted to fight your " the domestic current situation below

China also hard outside place oneself thing.

All the time since, china is antibiotics production big country. According to Beijing University the expert such as Professor Xiao Yonggong investigates clinical pharmacodynamics institute computative, china produces antibiotic every year about 210 thousand tons; Exit of eliminate raw material makes an appointment with 30 thousand tons outside, the rest is used 180 thousand tons in home (include medical treatment and agriculture to use) , average per capita year consumption is in 138 grams, be the United States 10 times the left and right sides.

Below this kind of setting, in August 2012, our country make known to lower levels history on the most severe bounds is fought your " antibacterial content is clinical applied government measure " .

According to this method, antibacterial content is able to bear or endure basis security, curative effect, bacterium the element such as property of a medicine, price, be used to be not limitation by cent class, limitation use class and special use class 3 level. Medical establishment and medical treatment personnel should master what content precaution affects use antibacterial strictly to point to proof, violate compasses use antibacterial the doctor of content, will by authority of prescription of warning, limitation, revoke hold industry letter, till investigate criminal duty.

2016, former state defends unripe family planning appoint, hair change appoint, the 14 branches such as total bureau of the inspect that feed medicine are made jointly and print and distribute " bacterium of keep within limits is able to bear or endure medical state action plans (2016-2020 year) " , implement integrated processing strategy and measure from national level, each link such as production of antagonism bacterium medicaments, current, application, environmental protection are strengthened superintend, encourage own research and development, should be able to bear or endure to the bacterium the risk challenge that medicine brings.

Effect sees at the beginning of effort.

In November 2017, former state family planning appoint release " government of Chinese antibacterial thing and bacterium are able to bear or endure medical current situation reports (2017 edition) " show, since 2011, utilization rate of our country antibacterial content, use intensity all shows downtrend, be in stabler level nearly two years.

Newest act comes from on April 1, 2019, national sanitation is healthy appoint release " had done antibacterial thing about lasting the announcement that clinical application government works " , make clear polyclinic of 2 class above to affect sexual disease division to want to created the infection ill division that manages bacterial fungus infection to be main disease with closing or medical treatment group before 2020.

"Be restricted to fight your " below, research and development of partial enterprise face about.

In May 2013, the lab that Hua Lansheng content approbates from World Health Organization obtained research and development of H7N9 flu vaccine to use poisonous individual plant, start the development of H7N9 flu vaccine formally, undertaking at present 2 period clinical trial.

2013, china's biggest antibiotic produces one of base the sea what medical industry and institute of medicaments of poison of martial academy of medical sciences develop jointly is new-style for the element that add annulus (Hai Zhengli star) announce to appear on the market. This medicine has the music that fight bacterium wide, bacterium of powerful effect antagonism is able to bear or endure the marked characteristic such as medicine, this also is the remedy that is used at treating super bacterium by the first of our country own research and development.

Nevertheless, at present the company wants the motive force that with great concentration develops new-style antibiotic is not powerful. "Domestic medicine look forward to basically is given priority to with be modelled on to the research and development of antibiotic, do not have innovation medicine basically. " CIC bright knowledge seeks advice from executive trustee Wang Wenhua to express.

2 class market is chased after hold in both hands under, more concept float at the surface. Before this, the product of industry of couplet annulus drug is vitriolic mycetozoan element piece be thought pair of super bacteria are useful, be heated up to fry by capital market for many times, but this company shows, the product is ignorred almost in the scale in company sale.

Only exception or come from Bai Yunshan.

By 2017, the natrium of amidine of Qin of Bao of new drug head below white Yun Shanqi and inject use natrium of amidine of head Bao Qin to receive clinical trial to approve, it is our country obtains approved head Bao successfully exclusively nearly 20 years kind 1.1 kinds of new drug.

As we have learned, from 20 centuries 60 time after element of bacterium of Bao of the first build comes out, appear on the market at present breed already amounted to more than kinds 60; But among them amidine of sulfur of only head Bao belongs to our country initiate, natrium of amidine of Qin of afore-mentioned head Bao is namely what on the foundation of amidine of head Bao sulfur the structure is transformed and get is brand-new compound.

Search those who cope with super bacterium " super " antibiotic, before the road is boundless.

Article put together is made up from " Chinese news weekly " , finance and economics of news of healthy times, interface, straight flush, before look up net, pharmacy net of economy of medicine of online, sina, financial, the first finance and economics, China.