The 3rd day of the 2nd class: For Nuofuwei ester and favour replace Ka Wei, which disease-resistant poisonous effect is good, is side effect little?
Attending section class, we learned to need to begin to fight virus cure and disease-resistant poison to treat commonly used medicaments what to have.
Today is the 2nd class of the 3rd day, we continue to tell patient of the liver that tell second's commonly used nucleotide with everybody kind medicaments is how to defy of second liver virus, on behalf of medicaments ester of Wei of the blessing that replace Nuo and favour replace Ka Wei, which disease-resistant poisonous effect is good, is side effect little?
It is text content below.
Nucleotide (acerbity) kind how is medicaments to fight second liver virus?In explain nucleotide (acerbity) kind before medicaments, what we see first is nucleotide acid.
Nucleotide acid is the fundamental unit that forms DNA and RNA, and nucleotide (acerbity) analogue is the child after nucleotide acid is decorated. Nucleotide acid and nucleotide (acerbity) between analogue, the structure is similar but the function is different.
If second liver virus begins a large number of duplicating, the nucleotide acid in liver cell is met by virus, decompose one by one, DNA of second liver virus is formed after recombining, resembling is to go all out like spelling a plan.
But, second liver virus divides acid of not clear nucleotide and nucleotide (acerbity) analogue, if nucleotide (acerbity) on the DNA that analogue spells him, because spell a graph not to match,the result is met, and bring about virus DNA to cannot continue to duplicate, this is nucleotide (acerbity) the principle of analogue disease-resistant poison.
Nevertheless also because such, nucleotide (acerbity) kind medicaments cannot destroy the virus DNA that has duplicated, that is to say, what can restrain virus only is duplicate, but cannot keep clear of thoroughly virus, because this needs to be taken for a long time normally, it is lifetime even take, if do sth without authorization stops drug, appear likely rebound.
(1) nucleotide (acerbity) kind medicaments does not depend on immune system, want virus to begin to duplicate only, can prevent
This also is why we say, want second liver patient to begin disease-resistant poison to treat only, can choose nucleotide acerbity analogue.
(2) nucleotide (acerbity) kind medicaments conduces to liver restoring
To having the patient of liver cirrhosis, must take nucleotide (acerbity) analogue. After be being restrained because of virus, because immune cell atttacks the inflammation reaction that cause to be able to disappear subsequently, can decrease to hepatic injury, conduce to hepatic refreshment.
The nucleotide that our country has appeared on the market (acerbity) kind medicaments is main: Rummy husband is decided, for decide than the husband, ester, favour replaces Adefuwei ester of the Ka Wei, Fu Wei that replace Nuo (TDF) . These a few kinds of medicaments should choose?
Basis " guideline of prevention and cure of hepatitis B of World Health Organization " :
The second liver patient that recommends the age that begins disease-resistant poison to treat strongly to be more than 12 years old, first choice is able to bear or endure not easily medical nucleotide (acerbity) kind medicaments, replace ester of Nuo blessing Wei especially (TDF) or favour replace Ka Wei (ETV) .
Do not recommend use incidental be able to bear or endure of medicine, decide like rummy husband (ester of LAM) , A Defu Wei (ADV) and for decide than the husband (LdT) . Because, the disease-resistant poisonous effect of these 3 kinds of medicaments is poor, virus is able to bear or endure property of a medicine is tall, now already medicaments of nonfeasance a gleam of is used.
Nevertheless, rummy husband can give 12 years old of the following children to use surely; Good for the gravid security that decides than the husband, the mother baby block that can serve as pregnant woman is broken with medicine (may cause muscle to injure nevertheless) ; Ester of A Defu Wei has the risk of disease of low phosphor blood and osteomalacia, do not recommend use.
For Nuofuwei a gleam of that ester is second liver prevention and cure is recommended with medicine, it defies virus result strong, gravid security is high, lactation also can be taken, and be able to bear or endure not easily medicine.
In the past, because replace ester of Nuo blessing Wei to treat cost taller, breed is less, it is relatively cheap that the patient can select the price more and the favour with more breed replaces Ka Wei. But as the Fu Wei that replace Nuo ester depreciates and bring into cure to protect, pattern of prices of these two kinds of drug is already similar. How should we choose?
Favour fight second liver virus for Ka Wei, be able to bear or endure property of a medicine is inferior, harmful response is smaller, it is more headache, cough, rhinitis, lack of power, on the circumstance such as bellyacke, suit to be used for a long time. But its disease-resistant poisonous effect is inferior to replacing ester of Nuo blessing Wei, and cannot use at pregnant woman, be decided with rummy husband and replace than the husband calm existence across is able to bear or endure medicine.
If rummy has been taken to the husband is decided or be replaced before the patient,compare a husband to decide, and had happened to be able to bear or endure medicine, cannot take favour for Ka Wei, meet this kind of condition, change ester of Wei of the blessing that replace Nuo, disease-resistant poisonous effect will be better.
Ester of Wei of the blessing that replace Nuo is almost OK sweep the deck is all be able to bear or endure second liver virus of medicine, and be able to bear or endure medical rate is almost 0. But, the risk of noxiousness of canaliculus of kidney of move of existence of ester of the Fu Wei that replace Nuo, take loss of function of likelihood occurrence kidney for a long time, the bigger to the age, patient that has nephritic disease, diabetic, high blood pressure, should take below the doctor's guidance.
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