A day in the morning, zhengzhou city is busying as usual in the clinical medicine course of hospital of the 2nd people.
Abrupt noise removes a hurried phone ring, apothecary of Director Wang Juan is received had a telephone call.
Citizen white aunt:
Hello, hear of clinical apothecary most be good at using drug, I seek advice presumably, one kind makes do obeisance to the medicine that is the same as newly, have a problem?Original, white aunt ate n of a kind of benzene calling saltpetre to accuse commentate piece (do obeisance to be the same as newly) medicaments, result the day before yesterday, the big at one's convenience that discovers oneself inadvertently has whole tablet actually, be afraid that oneself let an old partner look again giddily, did not misread as expected.
Her heart thinks: It is a person old, digest bad? If take pill apart, be digested easily?
Then the following day, white aunt proper motion cuts pill two valve to take, but strange is two valve pill or thoroughly eduction outside body.
It is oneself after all gastric bowel path is special, still buy false drug in drugstore?
So, one big early, she finds Zhengzhou city hurriedly hospital of the 2nd people refers a telephone call with medicine, want to look for professional apothecary to seek a help.
After Wang Juan listens, say: Do not worry about an aunt, this is normal phenomenon. . . . . .
The medicine of white aunt why " indigestible " ?The saltpetre benzene n that white aunt takes accuses commentate piece wore special " appearance " -- stuff of film of small Kongbao garment.
Bag garment uses small hole film to regard garment film as material in polymer of the indiscerptible in gastric bowel fluid normally, connect those who appear a gender to control medicaments effectively thereby to release to make film is had, in needing to including garment juice, join a few the agent that send aperture.
When medicaments and gastric bowel fluid are contacted, the agent sending aperture on film encounters digestive juice part to dissolve or fall off, small hole is formed on the film including the clothes of tablet or curve canal, make garment film is had appear a gender. Medicaments element passes these small hole to release play action to velar external diffusion.
And the film that include the clothes is not destroyed inside gastric bowel path, whole empty drug case is by bowel outside eduction body, this namely why white aunt can discover pill in defecate.
Make a common example, film accuses model delay accuses commentate preparation is equivalent to " pasty " , pastry of no less than is broken, defect comes out with respect to meeting leakage same, if this kinds of the form of a drug is broken, of medicaments release do not be able to control, so this kind of delay accuses commentate piece cannot break take.
On behalf of medicaments n of benzene having saltpetre accuses commentate piece (do obeisance to be the same as newly) , Glenn Bi Qin accuses commentate piece (Ruiyining) etc.
So, what white aunt pulls is only " empty shell " , the medicaments inside is early had been absorbed by human body ~
The delay of profess to convinced with the at present rapiddest development accuses commentate the form of a drug, press the principle of its preparation, accuse besides film model, still have framework model.
Framework
Framework delay accuses commentate preparation is medicaments is mixed not dissolve accuses at the delay of water commentate bead is made after material mixes through physics, the form of a drug that forms after sheeting.
Framework piece basically have 3 kinds of kinds: Corrosion sex framework piece, not dissolve sex framework piece with hydrophily gel framework piece, commentate medical mechanism each are not identical.
If film accuses model delay accuses commentate preparation is " pasty " , that framework delay commentate preparation resembles " jelly " , although jelly is divided into two half, the bag also won't come loose immediately in the fruit inside come out, still can withhold in jelly.
So framework delay commentate piece it is to be able to break those who take. On behalf of medicaments the United States holds Luo Erhuan in the palm commentate piece (times his Leke delay commentate piece) , delay of fat of Shan Li of different of odd nitric acid commentate piece (Xin Kang) etc.
Why should control such construction?Fluctuation of chroma of drug of common tablet blood is bigger, produce poisonous side effect more easily, and daily time giving drug is much, amount to 3-4 commonly second, reduced comply with sex of the patient greatly.
In the cure of a lot of diseases, the effect time basis that the doctor hopes to be able to let medicaments the demand of the body is controlled: The effect time that waits medicaments for instance, let medicaments arrive at specific place to be released again in the body...
Be based on above problem, medicaments by clever apothecary people made what contain gear so " mysterious pill " . Delay accuses commentate preparation is able to develop quickly from this.
Alleged delay commentate preparation, the department points to to after using drug, can be in long inside, can release medicaments element continuously, in order to achieve the preparation of lasting effect effect.
And accuse commentate preparation, the department shows medicaments can be inside booked time, release automatically with booked speed, make hematic drug chroma long constant maintain in the preparation in effective chroma limits.
In addition, still have alvine dissolve preparation, also be to contain " mechanism " medicaments the form of a drug. Medicaments is released again after this kind of medicines and chemical reagents can decide a dot to dissolve at alvine path, have a plenty of be opposite to reduce medicaments the undesirable action of gastric ministry, have a plenty of prevented to medicaments is destroyed by hydrochloric acid in gastric juice and lose effectiveness.
Wang Juan reminds: Encounter have " mechanism " when medicaments, in do not understand the case that uses drug to fall, never break at will take!
Break perhaps crumb, can destroy pharmaceutist intention fine suffer from a design " mechanism " , lost the result that wants to achieve originally thereby, because take chroma of the medicaments inside rear body,still may lift abruptly even, cause drug poisoning!
Different remedy, because produce manufacturer to differ, preparation technology is different also, specific it is which kinds of delay accuses commentate preparation, what is the note that takes drug, still need to read a manual in detail direct perhaps and professional apothecary. [the 2nd people of Zhengzhou city hospital Chen Yan]
