These two days, "Japanese star anticarcinogen appears serious side effect " news is unexpected went up to heat up search, caused the attention of a lot of people. Many people ask me through all sorts of ways, how to reply a thing after all? It is so dangerous really to use drug of the immunity that fight cancer?
The immune drug that mentions this in news (O medicine) be in China very famous, because it is the first PD-1 antibody that appears on the market in China,be kind medicine of the immunity that fight cancer.
This kind of medicaments is called by a few people " divine medicine " , compare because of action chart on one hand wide model, have effect possibly to a variety of cancer types, include lung cancer, suddenly strange gold is lymphatic tumour, melanin tumour, kidney cancer. On the other hand because although terminal patient is used hind have better curative effect possibly, implementation lives for a long time. For instance, o medicine lives terminal blame 5 of patient of cellule lung cancer years period, be less than from in the past 5% rose 16% , promoted nearly 4 times. This is a tremendous progress.
But this news irrigated cold water of one gourd ladle to a lot of people it seems that, is the secondary action of immune medicaments so strong really?
I very understand authority the mood of angst, but truth fact says, this thing can go up it is very accident that I return hot search, because the personage inside the industry did not discuss this thing at all actually, because this side-effect both neither of immune therapeutics is accident, also do not have so serious.
Outside saying this thing unexpectedlies, because immune therapeutics has side effect,be not be news completely. Include the cerebral ministry illness that mentions this: Pituitary is phlogistic, also be a kind of foregone immune therapy side effect, not only O medicine has, medicine of other and congener immunity appears possibly also. In the manual of O medicine, on the manual that includes China, had indicated this potential side effect. This morrow is only originally it alone and supplementary entered " main side effect " , remind doctor and patient to notice all the more.
Say this thing is done not have so serious, because the proportion of this kind of side-effect happening is very small,be, appear the proportion of serious symptom is smaller, understand according to me, china has not reported immune cure brings the case with serious phlogistic pituitary. Although say 11 people come on in Japanese news, the likelihood still caused 1 person death, but should calculate only have how many patient using immune drug, have benefit of how many person, knowing this accrual risk is compared can be accepted, not necessary and alarmed.
If say everybody can be harvested actively somewhat from this incident, that should be after although appear on the market,knowing medicaments, side-effect also should continue to be superintended.
Medicaments revises a manual, especially side-effect part, it is very common act.
The side-effect of medicaments some are commonner, some are relatively infrequent. Common side-effect needs the less number that use drug to be able to discover only normally, it is for instance in clinical trial. Contrary, because unusual secondary action produces proportion low, rely on clinical trial only insufficient still, after still needing to wait for medicaments to appear on the market, expand significantly as use crowd and increase ability to affirm with medical time. Why this is opposite namely of the medicaments after appearing on the market superintend still cannot lax, want to be tracked closely especially to side-effect.
Of course, the pituitary phlogistic secondary action that modifies this, everybody cannot be ignored. Use PD-1 depressor when, no matter import medicine, still be homebred medicine, everybody should know to have the possibility of all sorts of side-effect, understand semiotic characteristic, if appear, handle very in time.
Lending this second news, also want to emphasize the side effect of immune medicaments to everybody again.
Really, photograph comparing changes cure, very much even target to medicaments character, PD-1 kind the scale of serious side effect of immune therapeutics is very low, everybody need not panicky. But medicine 3 minutes of poison, with other remedy, immune treatment also has side effect, we do not recommend everybody to try blindly in disorder.
PD-1 depressor has effect, because it can compare strongly activation to be aimed at the immune reaction of cancer cell,be, achieve the result that exterminates cancer cell thereby. But in this process, hard to avoid also can activation a few immunity reaction that are not aimed at cancer cell, cause certain harm to normal cell, this produced side effect.
Immunity treats a series of brought secondary action to have an uniform name, cry " immunity is relevant and undesirable incident " (Immune-relatedadverse Events, abbreviate is IrAE) .
To PD-1 depressor character, this kind of side effect that because immune system is too active,causes may appear in all sorts of organs, especially the skin, gastric bowel, endocrine organ.
So much side-effect, look very fearsome, but the side-effect that actually great majority immunity treats is lighter, belong to 1 to 2 class, clinical management is not difficult. More important is, data shows, appear these side-effect, can not affect remedial result.
The introduction of side effect of more immunity therapy sees here please: What side effect can immune cure have? How to handle correctly?
Sum up simply:
Very important to appearing on the market to monitor and be evaluated of drug side effect, protecting patient security is the first forever.
whole, PD-1 kind immune medicine is serious side-effect proportion is very small, than changing cure, compare many target to be close friends to medicine even, need not panicky. Get used to disease to what be appeared on the market by approval and character, the integral accrual of immune therapeutics is more than a risk.
Immune cure is not all-purpose god medicine, also be not absolute safety. It has its distinct side effect, need close monitoring, do not recommend so use immune treatment blindly, and need is in next the doctor that has experience is directive use, convenient and seasonable identifying and manage immune secondary action.
Side effect of different immunity therapy may be distinct, so everybody should be abided by obtain batch appear on the market get used to disease, exceed not blindly get used to disease to use.
Lending this second news, hope everybody can know the fact that immunity treats better, include side-effect and risk management, reasonable with medicine, gain the biggest profit! Greeting life!
Bibliographical reference:
1: Small-Cell Lung Cancer of – of Nivolumabversus Docetaxel In Advanced Nonsquamous Non. N Engl J Med 2015; 373:1627-1639
2: Immune-RelatedAdverse Events Associated With Immune Checkpoint Blockade. N Engl J Med 2018;378:158-168
