PD-1 block is broken the gender is transferred in cure 3 electronegative breast cancer (Triple-negative Breast Cancer, TNBC) have inferior curative effect mediumly, this highlighted need development to let tumor small environment decide more sensitive strategy to PD-1 block. Clinical before research already pointed out change cure and the immunity that put cure to adjust characteristic.
Be not contrast in an adaptability 2 period in the first phase of clinical research, the researcher that comes from the research organization such as Holand cancer academy transfers sexual TNBC patient to undertake allocation randomly to 67, let these patients accept the following one of a variety of treatment program: (1) accept fierce sheet is fought, but without changing cure or put cure revulsive, not revulsive batch weighs below; (2) accept fierce sheet is fought, and accept 2 weeks of small dose to put cure (3? × ? 8? Gy) revulsive, next weighing that put cure team; (3) accept fierce sheet is fought, and accept amine of acyl of phosphor of annulus of 2 weeks of small dose revulsive, leave group of amine of acyl of phosphor weighing annulus; (4) accept fierce sheet is fought, and accept 2 weeks of small dose suitable platinum is revulsive, next weighing that arrange platinic set; (5) accept fierce sheet is fought, and accept quiet of mildew of A of 2 weeks of small dose revulsive, leave group of vegetable of mildew weighing A; All patients all use accept fierce sheet to fight subsequently. Near future of relevant research result is published on Nature Medicine periodical, paper caption is " Immune Induction Strategies In Metastatic Triple-negative Breast Cancer To Enhance The Sensitivity To PD-1 Blockade: The TONIC Trial " .
The picture comes from Nature Medicine, 2019, doi:10.1038/s41591-019-0432-4.
In this in whole alignment, objective reaction is led (ORR; IRECIST) for 20 ％ . Most reaction is in the group that arrange platinum (ORR 23 ％ ) with group of A mildew vegetable (ORR 35 ％ ) in observe. After A mildew element and suitable platinum are revulsive, these researcher detect the immunity in PD-1/PD-L1 and way of noxiousness of T cell cell is moved on relevant gene. After A mildew element is revulsive, turn with STAT of – of inflammation, JAK and TNF- α signal guide relevant on the rich market that moves gene supported this further.
This shows, the clinical data of this clinical research changes data to make clear short-term A mildew element and suitable platinic remedy may be revulsive small environment increases a kind of more advantageous tumour to break the possibility that makes response to PD-1 block to TNBC. These data still must be in TNBC undertake more confirming, and dug the possibility that develops revulsive treatment before undertaking PD-1 block decides remedy in other cancer type.
Reference material:
Leonie Voorwerk Et Al. Immune Induction Strategies In Metastatic Triple-negative Breast Cancer To Enhance The Sensitivity To PD-1 Blockade: The TONIC Trial. Nature Medicine, 2019, doi:10.1038/s41591-019-0432-4.
