Drug period of efficacy is quality of control medicines and chemical reagents and one of safe main index. Period of efficacy is to show medicines and chemical reagents is below certain reserve requirement, can carry the term of quality. To exceeding the medicines and chemical reagents of period of efficacy, according to " Pharmaceutical Affairs Law " regulation, already belonged to bad medicine. Expire medicine also is included " directory of national danger trash " , cannot reoccupy.
Somebody may examine minutely
The medicines and chemical reagents that why expires cannot reoccupy?
Used what harm is there?
What element can cause an effect to medicines and chemical reagents
Medicines and chemical reagents is inside period of efficacy, accompany the elapse of time, experience the effect of the element such as all sorts of physics, chemical, environment, can produce all sorts of change. Unit of national drug research, production appears on the market in medicines and chemical reagents before, all considered afore-mentioned impacts, and according to scientific method (stability makes an on-the-spot investigation, observation taking shape) parameter, made the period of validity of every medicines and chemical reagents, the time that assures quality namely paragraph. Once crossed period of validity, medicines and chemical reagents pledges the quantity assures hard.
The light
The ultraviolet energy in the light is great, it is the catalytic element that chemistry of happening of medicines and chemical reagents changes, long illumination can be caused directly or promote happening of medicines and chemical reagents oxidation, reductive, decompose, the chemical reaction such as polymerization, effect of change of occurrence colour and lustre, drug is reduced invalid even.
A lot of medicine are very sensitive to the light.
Oxygen
Aerobic property is lively, can make a lot of drug that have reproducibility happen decompose, degenerative, become angry. Be like ferrite, inferior mercuric salt kind medicines and chemical reagents, can be become by oxidation Gao Tie, tall mercury; Phenol reachs the drug that contains phenolic hydroxyl, be like salicylic natrium, herion, adrenalin, can be oxidized to make thing of red, brown Kun type coloured; Grease and oiliness fat ointment but because of oxidation acid is defeated; Vitamin C can oxidize generate go hydrogenous vitamin C; Adrenalin is encountered in air after light is oxidized namely invalidation.
Carbon dioxide (CO2)
CO2 can cause the change that PH is worth. Great majority medicines and chemical reagents must serve as medium through water, CO2 makes carbonic acid with water action first, produce new material thereby with medicaments happening reaction again next, if oxyhydrogen changes potassium,absorb CO2 and become potassium carbonate.
Humidity
Ester kind medicaments aspirin, atropine, monobel, Ding Ka because, bromic third amine too forest, inferior choline of ester of the fifth of the ten Heavenly Stem of nitric acid different, acetyl, inside ester kind the ester inside medicaments dextrose aldehydic acid, ester inside foreign the rhizome of chuanxiong, element of bacterium of Bao of penicillin of acyl amine medicaments, chloromycetin, head all easy hydrolyze, be affected with damp be affected with damp can be decomposed generate mellow or corresponding acid, acerbity, amine and invalidation.
Temperature
Exorbitant or temperature is too low can make medicines and chemical reagents degenerative. Unused medicaments asks to differ to temperature.
Used expire how is medicine met?
Medicines and chemical reagents expires to affect curative effect already
Bring toxicity possibly again
Cause all sorts of harm of human body
Expire the medicines and chemical reagents of invalidation, although some use naked eye observation to be less than apparent change on the exterior, but immanent change and bring harm predict hard. Affect curative effect not only (invalid, reduce effect) , illness of incur loss through delay, and bring various harm, for instance easy cause allergic, exciting, aching, toxic.
If why deal with to had exceeded the medicines and chemical reagents of period of efficacy
It is the medicines and chemical reagents to arrive or exceeding period of validity, must not use stoutly.
2 be expire medicine sends reclaim dot.
3 it is avoid by all means loses conveniently of medicines and chemical reagents the place that cast or is put in children to be able to touch, appear to be fed by accident in case or accident, or pollute an environment; Or be used afresh by adventurer.
Sweet clew
If you encounter food, health food, cosmetic, medicines and chemical reagents, medical apparatus and instruments in the life pertinent question, dial in time please 12331 undertake complaining informing against, also can send a message to be superintended to Jian Yang market through small letter platform.
