Smoke a blood to you can detect do you contract cancer? Two years ago, this is " fantasy " , but " today, we have data to show actually, it is very feasible that this is resembled to discovering the inchoate cancer in blood is slash, " institute of American Dana-Farber cancer and Geoffrey R of haing Buddha college of medicine. A of Oxnard M.d. newest research shows as a result. The metaphase of this newest research is analysed, this research compared 3 kinds to detect methodological function, in order to measure more than 1000 free cell DNA of philtrum, include patient of many 150 lung cancer among them. Consider to discover, why to no matter use,plant detect method, the case of inchoate lung cancer that has 50 ％ about can detect come out, rise to the 90 ％ of terminal case.
Exsanguinate investigates cancer is not a dream
Famous ASCO expert, come from north to block Luo Laina city when Dr. David Graham of center of medicine of Carolinas of Xia Luo spy comments on these new achievement, say, this is " a kind of very exciting new methodology " , and be " the first step with discover with easier way inchoate lung cancer was stridden important forward " , so that be in,earlier phases discovers cancer, achieve cured goal then. He thinks " if the result of this research is confirmed, we can see easily, some day, certain person may need to enter their normal hospital only, the arm since Lu draws one canal blood, OK easy to do sieve investigates lung cancer, OK easy to do sieve investigates lung cancer,,
Haemal circulation cell
Such test can raise lung cancer to sift the effect that investigate, although be checked to the sieve of lung cancer now,always emphasize small dose CT (LDCT) importance, but the sex of potential radiation hazard as a result of CT, let many people flinch, check rate photograph to check scale of lung cancer crowd than LDCT sieve with the sieve of other cancer very low still. According to the report, 2016, be in the United States that develop in the near 7 million crowd that accords with lung cancer sieve to investigate a condition, the person that is less than 2 ％ only accepted LDCT sieve to check.
On ASCO press conference, m.d. of main investigator Oxnard says, the analysis of first time metaphase of this research makes clear " the measures foreword to be able to produce high quality in whole gene group in the round data of free cell DNA, and can undertake be not the cancer that invades a gender to detect. " he thinks: "These result support use what free cell DNA is a foundation to detect the perspective that methodological development has the inchoate cancer check of tall particularity to check check. " he points out, these detecting method " can cross level, cross histology, cross group be careful in one's conduct to measure lung cancer " .
CT sieve is checked
In their research, oxnard and its work in the same placing considered to pass the feature of appraisal mutation, whether had decided cancer gene with Yu Jian cent the free cell of specific mutation is based on DNA it is OK to detect more use at cancer widely inchoate sieve is checked detect. They built a collection of illustrative plates of group of circular cell gene to consider (CCGA) , this research is mixed from the United States up to now 142 places recruit of Canada 12, 15 in 292 plans, 000 each body, among them 70 ％ have the cancer that did not treat, cancer of 30 ％ dispute contrasts. Single out 2800 people from which, cent is 1785 people (127 people contract lung cancer) participate in with 1015 people (47 people contract lung cancer) , odd 12, 200 people are used at prospective test and verify to consider. The lung cancer patient that they selected to 118 can be evaluated and can be analysed from which and 561 blame cancer contrast patient, chose patient of 46 lung cancer and 362 blame cancer to contrast from which patient, the feature of base line population of two groups of crowds is similar.
Lung cancer sieve is checked
Researcher used the free cell DNA of 3 kinds of different types to measure foreword to analyse a method next: The target that is used at detecting to be not mutation of farther body cell to determine, include odd nucleotide acid aberrant and small insert / be short of break; complete gene group measures order in order to detect hydrogenous salt measures the sulphurous acid of complete gene group that copy of body cell gene counts DNA of cell of metabolic; and dissociate what foreword indicates apparent heredity to change with detecting is unusually methylic change pattern. Crucial is, these detecting DNA of methodological use leucocyte filters rate of technical general false positive reduces 2 ％ , particularity is 98 ％ . Investigator explanation says: "Leucocyte contains a lot ofmutation, may pollute DNA, make you think to cancer exists in free cell DNA, pour out of from inside white blood cell actually. " " the interference that you can choose a leucocyte and noise of other live thing to cause, leave last feature next - choppy, copy number mutates and methylic change a feature - enter next determine finally into what studying. Copy number mutates and methylic change a feature - enter next determine finally into what studying..
Study the result shows, why to no matter use,plant detect method, in training concentration all detects 41 ％ (29 ％ come 54 ％ ) inchoate lung cancer, the definition comes for I IIIA period. Test concentration, detect 50 ％ (29 ％ come 71 ％ ) inchoate lung cancer. To terminal lung cancer, the definition comes for IIIB IV period, it is better to determine to be behaved as a result, the case of illness of 90% gets test and verify in the test.
Lobar examination
Study the result is admittedly worth while and delectable, detect through blood to inchoate cancer the sieve is checked, let people be full of enthusiasm, but the time that still has a few years possibly before this kind of any tests can be used in clinical practice. Article of an ASCO column undertook assessment to this domain recently, conclusion is current " show without evidence clinical and extensive practical, with the clinical test and verify that reachs Ct DNA of tumour of inchoate cancer loop to detect, the evidence that cure is monitored or rudimental disease detects. The evidence that cure is monitored or rudimental disease detects..
In light of clinical angle, it is special that the haemal examination of inchoate lung cancer will come " welcome " , market potential is boundless. Also observer thinks this research undertakes very well, but the patient number that lung cancer includes inside in the design " a bit low " , because this emphasized the demand to determinism research. In addition, when applying check of free cell DNA to check check to more extensive crowd when the consideration, should consider " detect can reach gender and detected cost. " if cost is too high, so a lot of patients cannot be accepted. Such technology becomes so not practical.
