[Aercihaimo disease: Why insulin can become new hope] Johnson announces recently, after safe problem appears, the clinical trial that stops a pharmaceuticals of new senile and gawkish disease. This one newest failure increased tens of large, costly clinical trial, these experiments are treating respect of this one annihilative disease to did not show any results.
More and more failure should let us stop want, whether did we make a mistake the reason of senile and gawkish disease? Planting to this of the disease in be being analysed first, the cerebra of the patient that German doctor observes to one dies at this kind of disease appeared to change strangely, she identifies the protein aggregation that gave two kinds to do not have discovery in young cerebra, the spot that discovers between cerebral cell and cerebral cell namely piece. The research later discovers, the protein that makes spot piece is amylaceous appearance albumen, and forming intricate albumen is TAU albumen, these structures still are discussing actually in.
Scientist of German doctor proposal does not want absurd to make conclusions say these protein caused this kind of disease. Unfortunate is, his discretion was ignored, come for years, scientists think these are accumulated proteinly from beginning to end caused Acihaimo disease. A problem is, if this theory is correct, be impossible to examine in scientific test. Till the last few years, ability develops people to be able to detect the technology of these protein functions, and apparently, this is not a scientist foregoing tentative ideas.
For example, the mice of gene project accumulated albumen of human starch appearance in its cerebra, show slight loss only. But pharmacy line of business maintains amylaceous appearance albumen a long time ago is a culprit, since then, amylaceous appearance albumen is the target of medicaments of Aercihaimo disease all the time. The purpose of these medicaments is the formation that carries protein of appearance of slow down starch or move its from inside cerebrum the level that eliminates albumen of appearance of the starch in reduce cerebrum. These two kinds of methods had undertaken for many times checking with different technique and medicaments type now. These experiments did not show any results. The abidance of new pharmaceuticals the reason that invalidation can explain to amylaceous appearance albumen is not Aercihaimo disease. A few companies already albumen of target instead TAU. But, pharmacy company still thinks single protein is the cause that causes this kind of disease.
Perhaps be moment reviews this kind of disease thoroughly. A kind of method is to seek the gene that increases sicken risk. The problem of this kind of method depends on, these gene are exceptionally little, and very infrequent. Aercihaimo disease is not caused by gene mutation it seems that, so this kind of method did not announce potential process.
Another kind of choice is the critical factor that considers to develop senile and gawkish disease. Among them one of namely 2 model diabetic. Apparent, diabetic have with Aercihaimo disease very big different, so what is the connection between both?
Be in diabetic in, the action with smooth to controlling blood sugar water insulin is abate. But insulin is control blood sugar not just, be " grow an element " . Nerve yuan special depend on grow factor, if they cannot get enough nutrition, with respect to meeting death. The insulin in cerebrum grows the forfeiture of factor effect makes it seems that nerve yuan get easily the influence of pressure, reduced the capacity of the loss that cerebrum rehabilitate accumulates along with time. Nerve yuan grow like life and us, so a lot of time produce loss. When the head that extracts from body of patient of senile and gawkish disease when research is organized, researcher discovery, although be in blame diabetic, insulin also lost the action that serves as unripe chief factor. This observes the result makes clear, diabetic medicaments may be the effective treatment method of patient of Aercihaimo disease.
A few experiments obtained the kill that makes a person impressive in animal experiment, and had begun a few clinical trials. The animal that retreats disease of handkerchief of travel sex disease Jin Sen in another kind of nerve checks these medicaments to also show the result that makes a person impressive in the model, two when undertake on body of patient of Pajinsen disease clinical trials show favorable protective effect. Amid experiments in, accept diabetic medicationed patient did not appear inside two years any aggravation, and accept what the standard treats to contrast group of serious aggravation. Another experiment is a bigger test, use comfort an agent to contrast, confirmed this one result, in showing the research in 12 months, this groups of medicaments do not have aggravation. Any protective action that discover cerebrum in clinical trial are brand-new, it supported the new theory of Aercihaimo disease and Pajinsen disease, because cerebrum lack grows,be partly at least factor activity. These development that are these diseases newly theoretically offerred new perspective, increased to develop a kind of medication possibility that can produce different result.
