Why to plant no matter patient of type coronary heart disease, all should take him for a long time to low kind of medicaments, make LDL-C<70 Mg/dl (1.8 Mmol/L) .
Already evidence of enough abide card medicine confirms, he lows kind medication can reduce cholesterol of low density lipoprotein (LDL-C) level, reduce disease of heart and vessels of sex of sclerosis of arterial congee appearance (ASCVD) the deadly rate, rate that cause damage. But partial patient is not able to bear or endure he what get high dose lows, and as a result of his lowing curative effect 6% effect namely the times LDL-C when adding reduces a kind of any his lowing dosage further extent is made an appointment with only 6% , and harmful response raises significantly.
For this, " fat of Chinese adult blood is unusual guideline of prevention and cure (2016 revised edition) " level of base line of fat of blood of proposal basis patient is initial use moderate strength he lows, mix according to the individual curative effect that move fat be able to bear or endure get a case, adjust dosage appropriately; If cholesterol level does not amount to mark, with its he moves fat medicaments (if depend on,fold Mai Bu) associated application.
However, his lowing combination is not small dose he lows how is effect of the therapy that move fat still clear about kind of medicaments, " American cardiology magazine (JACC) " a research undertook discussing around this problem, result how? With small make up look together ~
Research introduction
This is before look up sex contrasts randomly odd blind experiments, brought into in the past 12 months had accepted classics Pi Guan 100 intervening cure of arteries and veins (PCI) , LDL-C ≥ is 70 Mg/dl, tall dosage he lows to not be able to bear or endure the patient of coronary heart disease that get, accept small dose randomly he lows + according to the cloth that lose a surname (10 Mg/d) / nutrient health care is tasted (Armolipid Plus, ALP, qd) cure. The main terminus of research is to fall jointly the rate amounting to mark of LDL-C of the person that fat treats future trouble.
Express 1: Small dose he lows + according to group of the cloth that lose a surname and small dose he lows + the base line feature of ALP group
Study a result: His lowing combination is not small dose he lows kind of medicaments, fall fat amounts to mark to lead 92%
After treating 3 months, the result shows small dose he lows + have 33 patients according to group of the cloth that lose a surname (66 ％ ) LDL-C amounts to mark; Small dose he lows + ALP group has 31 patients (62 ％ ) LDL-C amounts to mark (＜ 70 Mg/dl) . Odd LDL-C did not amount to the patient of mark, accept small dose he lows + according to the cloth that lose a surname + ALP is triplex after treating 3 months, have 28 patients (78% ) LDL-C amounts to mark, average LDL-C is 69 Mg/dl.
Graph 1: Study flow chart
With small dose he lows + compare according to appearance of group of the cloth that lose a surname, small dose he lows + ALP team is average LDL-C falls bigger (- 16 Mg/dl Vs. - 26 Mg/dl, p <0.00001) , fall total cholesterol effect is more distinct (- 16 Mg/dl Vs. - 27 Mg/dl, p=0.0005) .
Express 2: Small dose he lows + according to group of the cloth that lose a surname and small dose he lows + ALP group falls of fat effect quite
Overall and character, his lowing combination depends on small dose the cloth that lose a surname / ALP falls the rate amounting to mark that fat treats 3 months LDL-C is 64% , the rate amounting to mark of 6 months is as high as 92% , patient LDL-C drops on average 33 Mg/dl, did not discover apparent side effect.
Graph 2: Mixed in March the research result June
Fall jointly fat cure, he lows is a foundation!
Surround the happening of operation period complication to decrease or avoid patient PCI, make clear domestic and internationally south each thumb, PCI patient surrounds operation period to medication crucial. " guideline of intervening cure of artery of shape of Chinese classics Pi Guan (2016) " point out, why to plant no matter patient of type coronary heart disease, all should take him for a long time to low kind of medicaments, make LDL-C<1.8 Mmol/L (Ⅰ , a) .
For this, " American cholesterol ran a guide 2018 " in recommending ASCVD patient to use advanced intensity he lows kind of medicaments is initiative cure, if hematic fat still did not amount to mark, can add on his lowing foundation with be not him to low kind of medicaments. General cut down he lows is benefit of a kind of lifelong heart and vessels is made clear and he security is good lows kind of medicaments, to needing to reduce the patient of LDL-C level further, medicable combination depends on the cloth that lose a surname.
This shows, he lows still is ASCVD falls the core medicaments that fat treats, his lowing combination depends on small dose of this research clew the cloth that lose a surname is had likewise fall clearly fat benefit.
The expert is commented on
Accessary Beijing installs medical university of Wang Changhua capital chastity hospital
Cut down of actor choosing general he lows, long-term benefit is safe and clear, reliable
He lows kind of main effect it is the synthesis that reduces cholesterol, depending on the main effect that discounts Mai Bu is those who reduce alvine path cholesterol absorb. Accordingly, he lows to have good complementary sex with the action mechanism that depends on the cloth that lose a surname, both combination application can produce good synergism.
This research shows, according to the cloth that lose a surname and small dose therapy of his lowing combination can rise considerably fall fat curative effect, achieve high dose he lows kind remedial effect, and without apparently harmful response.
General cut down it is light that he lows in unusual patient moves the fat that spend blood for a long time fat actor is chosen, have the following advantage:
One class prevents: Card of sufficient abide of MEGA, WOSCOPS supports, contented patient falls fat amounts to mark demand.
Long-term benefit: LIPID 16 year, WOSCOPS 20 year along with visit research, clew general cut down it is long-term that he lows the first choice of patient of his lowing cure.
Safe and reliable: The water-solubility that does not metabolize via CYP450 he lows, reduce medicaments interaction, promote viscera security in the round, worth while and clinical recommend.
Foliaceous benefit square Zhejiang visits people hospital
Intensity waits in recommending initial choice his lowing cure
More and more research make clear, high strenth he lows (daily his lowing dosage reduces LDL-C ≥ 50% ) cure is accompanying taller myapathies and liver enzymatic ascendant risk, more outstanding in Chinese crowd.
" fat of Chinese adult blood is unusual guideline of prevention and cure (2016 revised edition) " also recommend clinical on basis patient heart and vessels is overall risk and level of hematic fat base line are initial use moderate strength he lows (daily his lowing dosage reduces 50%) of LDL-C 25 ～ , mix according to the individual curative effect that move fat be able to bear or endure get a case, adjust dosage appropriately.
Make clear toward research already, the fundamental the first line of a couplet on a scroll that in groovy dosage he lows adds up to use blame he lows cholesterol absorbs kind of medicaments depressor depends on the cloth that lose a surname, can reduce main end event significantly, if cardiovascular death, blame is deadly,cardiac muscle stalk dies and wait in soldier.
This research hints, to large dose he lows to not be able to bear or endure suffer, the patient that cholesterol level does not amount to mark, can use he what adjust dosage lows and treat strategy jointly according to the cloth that lose a surname, notice to monitor harmful response.
The first people of city of Li Zhenci Guangzhou hospital
Small dose he lows + fold Mai Bu or depending on is the feasible plan that move fat
Patient of extremely tall to etc of coronary heart disease of our country great majority danger, groovy dosage (moderate strength) his lowing cure or combination can satisfy his to fall namely according to the cloth that lose a surname fat demand. And association of heart of newest United States / American cardiology learns (AHA/ACC) cholesterol management manual also is in ASCVD2 class precaution the proposal gets dose to can be able to bear or endure most he lows kind of medicaments blood fat the patient that does not amount to mark, can use " he lows + according to the cloth that lose a surname " cure is politic, and consider to make clear, low with him with sheet quite, according to the cloth that lose a surname and his lowing combination, LDL-C can drop further 19%-23% .
Article document also confirmed use small dose his lowing combination depends on the cloth that lose a surname (or) nutrient medicaments to large dose the patient of coronary heart disease with his lowing invalid cure is feasible, the remedial program that reachs safety effectively.
Bibliographical reference:
[1]Usefulness Of Low Dose Statin Plus Ezetimibe And/or Nutraceuticals In Patients With Coronary Artery Disease Intolerant To High-Dose Statin Treatment.The American Journal Of Cardiology.2018.
