In nerve science domain, a huge argumentative central issue is, the nerve in human cerebra yuan whether can you update ceaselessly in lifetime? Still stop development in cerebrum later (namely after teenage period) , won't does a course that the name produces for nerve produce repass new nerve yuan?
This one problem can initiate a debate, because save in good condition cerebra to organize example,partial reason is actually very little, and identify immature nerve yuan the technology also has each different.
Last year March, the person such as nerve scientist Arturo Alvarez-Buylla and Shawn Sorrells discovers in a research, in the sea horse area that concerns with study and memory, new student nerve yuan the amount can begin to decrease after be born, nerve of this kind of newborn yuan the amount can fall in grown period almost to for 0. Research is published to be in as a result " natural " on periodical, to such result, a lot of nerve scientists express cannot complete be convinced.
Now, a new research makes clear, although already the person is too middleaged, a new cerebral cell also can be made in cerebrum. And a few research in the past fail to discover new cell, the possibility is created.
To newest research result, the neurology home Paul Frankland of disease child hospital says Canadian Toronto, this research was offerred " clear, clear evidence, show nerve produces the lifetime of can perforative person. Show nerve produces the lifetime of can perforative person..
Long-term since, researcher hopes nerve happening can help cure all the time depressed disease and the cerebral ministry disease such as disease of silent of A Erci sea. But according to a year before that is published in " natural " the report on periodical, this one process can begin to disappear before adolescence. Such discovery lets a lot of nerve scientists feel depressed. For example, the grown nerve that what Frankland studies is area of rodent animal sea horse happens, such result let Frankland generate doubt to what work with oneself.
By Saiweiluo Aoqiaoya the N of í of neurology home Maria Llorens-Mart of molecular biology center and her colleague finishs newest research jointly. Llorens-Mart í N thinks, a few research in the past may exist on the method problem. With that is published in last year " natural " the research on periodical is exemple, use in 59 when the person such as Sorrells uses search new nerve yuan in specimen of human brain tissue, one sample with partial comes from cerebral library. These example connect regular meeting to be secured in much polyformaldehyde a few months immerses to be counted even in fluid year.
Time one long, much polyformaldehyde can be in form nerve yuan key is formed between composition, turn the cell into gel. This meeting makes fluorescent antibody very difficult with double coriaceous element (DCX) union, and DCX is be regarded as by a lot of scientists crudely nerve yuan " gold " mark. The person such as Llorens-Mart í N discovers, the DCX in cerebral tissue detects the cellular amount that shows masculine gender is immersing in much polyformaldehyde after 48 hours drop quickly. Accordingly, wanted to immersing the nerve with the new discovery in the brain tissue after 6 months yuan, nature is almost impossible.
Then, in new test, what they use is 13 fixed time shorter (24 hours) the head organizes example, the age of example subscriber arrives 87 years old in 43 years old between. This, they are in of sea horse area dentate several DCX electropositive cell discovered in answering. Dentate answering is a paragraph of inside sea horse body curly organization, it is in charge of having code to the memory of incident. Below microscope, the nerve that Llorens-Mart í N and her work in the same placing discovered to these have young feature yuan, they are smooth and plump, have simple and not the branch of development.
In the youngest subscriber (43 years old die) in example, there are 42 thousand about in studying the group discovers the head of every square millimeter is organized such crudely nerve yuan. Arrive from the youngest subscriber the oldest subscriber, new student nerve yuan the amount decreases apparently 30% . Study the group returns discovery, with with age healthy dedicator is compared, of the dedicator that contracts disease of silent of sea of A Er Ci crudely nerve yuan the amount wants little 30% , and illness the more serious, crudely nerve yuan the amount is less. They publish this one result in " natural medicine " on periodical.
To new research result, still a few scientists support distrustful attitude, among them the sound of a kind of criticism is the coloring that is aimed at DCX. The author Sorrells of that paper was opposite this a little bit to have veiled word quite likewise last year, his explanation says, DCX coloring is not to measure young nerve yuan appropriate level, because the expression of DCX albumen also exists in mature cell. Accordingly, this may mean the person such as Llorens-Mart í N to discover " new " nerve yuan the nerve that already existed from children period actually yuan. He still points out, new research also does cellular pool to be able to offer new nerve without discovery yuan evidence. More important is, sorrells expresses, in that research last year, two cerebra example is in only in much polyformaldehyde secured 5 hours, but they still did not find young nerve in sea horse area yuan evidence.
To this, the response of Llorens-Mart í N is, come from to affirm DCX electropositive cell is really at young nerve yuan, her research group was used with nerve yuan a variety of other protein related development, and they are used at identifying young nerve yuan standard " very severe exacting " .
Of course, this one research is remaining as a result the examination of group of other scientific research and reproduction, but the support that it had harvested scientist of a few nerve. For example, the neurology home Heather Cameron of institute of beautiful country mental hygiene states she believes new research result, although argue to be able to be not appeased because of this probably, but we are moment self-confidence ground strode this problem final judgement ahead. What make a person expect more is, new research offerred a kind for us probably as a result new likelihood, be prevented namely or the nerve with new changeover yuan grow decrease, can the development of disease of silent of sea of Ci of Er of slow down A.
Https://www.sciencemag.org/news/2019/03/new-neurons-life-old-people-can-still-make-fresh-brain-cells-study-finds
Https://www.nature.com/articles/nature25975
Https://www.nature.com/articles/s41591-019-0375-9
