The invention time of new drug normally very long, cost tens of year, and in arrive from clinical test in the measure of the market 10 do not put one. The reason of tall mortality is very much: Cannot repeat however on the magazine that experimental result publishs in read and appraise of course person of the same trade, the result of experiment of very few, animal cannot use optional animal test on human body directly, the height of disease and patient group is heterogeneous gender (heterogeneous sex is, its pathogeny each are not identical. For instance diabetic it is disease of a kind of heterogeneous sex, it is a diabetic likewise that is to say, his genetic defect is possible each are not identical, the function of environmental element is not same also, its are treated must height is individual change) and scientist, controller, venture capital investment person, medical company and the information asymmetry between the person that superintend are waited a moment. Chemistry of haing Buddha university teachs Al á N Aspuru-Guzik to also do not decide, but he seeks the solution through software, namely the molecular structure that imitate has structure of element of two kinds of medicaments.
Artificial intelligence (AI) the program can help discovery new-style medicaments composition. Apt uses medicaments synthesis experts software is in giant, accord with chemical fundamental await in choosing medicaments element structure, search, mix to what identify at the same time the active member structure that forecast undertakes imitate. Of former support is the mankind the acknowledge to everythings on earth, and the restriction of computational ability institute that latter criterion is needed by simulative accuracy and place.
Aspuru-Guzik system can figure at undertaking besides the mankind independently, and without lengthy imitate process. It from inside the database thousands of kind of medicaments element structure is medium absorb knowledge, use machine study algorithm to build his " experience " . "It resembles a chemist same, the reflection that the chemical knowledge that uses institute study will come to have instinctive sex " Aspuru-Guzik says, "What the mankind can do is better, if if have this kind of software,becoming their assistant " . Aspuru-Guzik is by nomination " MIT science and technology is commented on " the person that the youth of 2010 year innovates.
This new system is to build what go up in machine study technology " deepness study " over, this kind of technology is in large Internet company already very general, but still use rarely in science domain. What it uses is proliferous mode, use namely already some knowledge, yield next potential new data.
The representative application of proliferous mode is to use it to yield picture, speech or character. Apply on email in Gu Ge's Smart Reply for example. But be in Toronto university and Cantabrigian university last month, aspuru-Guzik and the work in the same placing of haing Buddha published 250 thousand when use proliferous mode generation kind of medicaments element structure. This system can give out a lot of likely new structures, if will show the medicaments element of some different function to undertake assorted, still can give out the result that a few specific function are like dissolvability, easy synthesis to wait.
The artificial intelligence machine of Insilico Medicine company is chosen with offerring remedy
The wind that Stanford university chemistry teachs Vijay Pande and him casts company co-worker Andreessen Horowitz to think this project can become machine study to change the another favorable testimony of scientific research. He says: "Deepness study software can let a machine have immanent chemical knowledge, use help scientist. It has very wide application perspective, effect can be produced in search and optimizing forerunner compound, or other domain is like solar energy and activator to wait. " researcher has trained a system in the database that uses element of an organic LED, but the chemical skill that distance technology maturity still needs to raise it, because of a few results that occasionally it gives out very foolish.
A challenge that Pande says to make software study chemical is investigator the optimal data form that has not been used at providing chemical structure deepness study software certainly. Image, speech and text already were proved to suit very much, and software can be mixed in image and speech recognition rival with human photograph on the interpreter, but the method of existing encode chemistry structure may be not complete correct. Aspuru-Guzik and his work in the same placing also are considering to join new character to be led in order to reduce chemical mistake to his system. He still hopes to be able to give a system more data, widen his chemical knowledge. Same, the database of 1 million pieces of pictures also can increase its picture acknowledge capacity. Chemistry can have the United States to had published the chemical structure of nearly 100 million in the database, soon, aspuru-Guzik system can give machine study them entirely, build his AI project thereby.
