108 volunteers and new coronal hope vaccinally

Up to on April 2, the first phase of new coronal vaccine that has in Wuhan suffers the person that try 108 times of clinical trial to already all finished have an inoculation, among them 18 volunteers end segregation. Each removing CT should be patted when segregation, condition of eye predecessor system all good.

In new coronal under the setting of craze of pneumonic whole world, vaccine becomes the hope that can resolve the crisis effectively most. Difficulty of even if research and development is heavy, the whole world still has 60 many vaccinal projects to try to near an end in hard land.

Li Xiaojie of exercitation reporter ｜

Reporter ｜ Wang Shan

Still have 4 days, chen Mengqiao can come out from segregation hotel. He this year 34 years old, it is to participate in new coronal vaccine one of 108 vaccinal volunteers that Ⅰ period experiments. According to the regulation, after have an inoculation, he should keep apart 14 days. If not be before inside a week alar those who sticking is automatic measure Wen Yi, chen Mengqiao did not feel his life and others have what different: Controlled at 8 o'clock everyday eat breakfast, chat with the friend later, play game, perhaps read electronic book, if be free, he still can take a paper to become bump is like the football on the foot, ego recreation -- the mobile phone that measures Wen Yi and him is linked together through the program, once his temperature exceeds 38 Celsius to perhaps measure Wen Yi to fall off not carefully, the mobile phone can shake, the staff member that is in charge of detecting at the same time also can come over to examine a case rapidly.

Chen Mengqiao was on March 16 in a small letter group in see sign up collect. Conditional requirement is very simple: Is the age in 18? 60 years old between, healthy, without new coronal pneumonic medical history perhaps is affected history, without vaccinal have an inoculation allergy history, wait a moment without contagious disease. Chen Mengqiao feels he is appropriate, his body is good, forward still is when playing football. Chen Mengqiao is person of door of Hubei chaste tree, the home was brought early in Wuhan, he learns film one's previous experience, those who like to take this city is lively the lamplight with all sorts of color after at nightfall. Before epidemic situation is eruptive, he takes parents to answer native place to spend the New Year. After sealing a city on January 23, group of his a lot of friends weaves volunteer team, money gives money, strong exert oneself, he is answered however do not go, good Wuhan was returned not easily through applying for ability March 10. "Just see a link, signed up rapidly. Signed up rapidly..

Chen Mengqiao still does not know in those days, by project of biology of academy of medicine of military affairs of martial academy of sciences joint-stock company of institute and Kang Xinuo biology develops they wait for vaccinal vaccine jointly, it is home first are obtained batch have human body the new coronal of clinical trial is vaccinal, be called " recombine virus of new-style coronal shape (2019-COV) vaccinal " . The controller of the group is Chen Wei of academician of researcher of academy of medicine of military affairs of martial academy of sciences, Chinese Academy of Engineering, she once was in after rich of West Africa dust pulled virus to break out 2014, guide group success research and development to give Aibola vaccinal. As vaccinal as the Aibola at that time same, the vaccine that enters clinical trial this also was to use gland virus to serve as carrier. Gland virus is the pathogen with common common cold, researcher knock off it causes ill crucial gene, make after its enter a cell cannot proliferous, do not constitute menace to human body. Subsequently, they will be new gene of albumen of coronal virus S (the main weapon of new coronal virus) conformity enters gland virus -- the gland virus that serves as carrier resembles a car, taking gene of albumen of S of new coronal virus to be in immune system of the mankind " freely " , let immune system memorize the pattern of virus, make antibody then, react quickly when virus inbreaks truly.

Come from link say, vaccine is in before appearing on the market, the clinical first phase with need rigorous course, 2 period, 3 period experiment, in order to check vaccinal security, effectiveness and stability. The purpose that clinical first phase experiments is a proof after vaccinal infuse body whether enough security. Sign up the number that joins a trial exceeds 4800 people. The person such as Chen Wei wants the first thing that do, it is to want to will accord with conditional person to be chosen. "This vaccinal clinical trial is in Wuhan, what we search is healthy volunteer. A few patients may be encountered to perhaps affect the person with new pneumonic coronal in this process, we need to eliminate him. " a staff member that participates in vaccinal and clinical first phase is being accepted when interviewing, express, they listed a variety of 30 requirements when choose, include red Huang La 3 kinds of color them according to the circumstance, "Gules delegate is put in certain and potential risk, have disease of sex of a few foundations for instance, do not suit to do the person of vaccinal and clinical research, cannot he comes to recruit; Maize delegate can not come; Blue is to accord with many 30 requirement basically, of mark blue and yellow make an appointment the personnel that register, need phone goes further check, whether can come certainly according to verifying a condition " . Farther phone communicates the their can dichromatic to bringing into Huang La person that sign up, "We ask that we must be waited for inside volunteer half an year in Wuhan, cooperate to consider to follow visit, if he wants this half an year,go out, leave Wuhan, that does not suit. " this staff member is being accepted when interviewing, say. Finally 200 people attend check-up, 108 people bring into experiment vaccination.

Chen Mengqiao is the announcement that signing up to be received the following day, when he still remembers check-up, as him the person of age is compared much. Before check-up, the doctor is ordinal call everybody in the room, show to them " know the inside story agrees with a book " , explain the purpose of the project, risk, need the work that the volunteer coordinates, still mentioned the secondary action after vaccination, if osculatory place is red,include, give out heat likely, muscle ache. "The content that the doctor gets on book told to me, he is told giving out heat is few phenomenon, if have,concern can be exited at any time. I feel it doesn't matter. " Chen Mengqiao says to this print journalist. It is the check-up content with firm order subsequently: Measure assay of temperature, exsanguinate, cardiogram, pharynx mop still was taken later child with anus mop child do nucleic acid to detect. The person of exsanguinate is a nurse, other handlers is a doctor, everybody is wrapped in tight defend take in, still wore blinkers. "The first phase of vaccine of gland virus carrier is clinical experiment, a few people make normal case example is enough. 100 many suffer the person that try vaccination, meaning this research is not the first phase on traditional sense any more clinical, have the consideration of deeper administrative levels however. " Wu Ke says to this print journalist. Wu Ke is Wuhan rich limited company of fertile biology science and technology (the following abbreviation " Bo Wosheng content " ) CEO, bo Wosheng content is the commercial company of vaccine of a research and development, in product line of its vaccinal research and development, virus carrier technology is among them a kind.

Before have an inoculation, everybody took a number. Chen Mengqiao 37, it is medium the first person of dosage group, want have an inoculation 1 milliliter is vaccinal. The vaccinal dosage of small dose group and high dose group is mixed for 0.5 milliliter respectively 1.5 milliliter. "The set of different and vaccinal dosage is the safe and effective dose that seeking vaccine. Ask to be vaccinal dosage setting when clinical trial commonly advanced and low, medium, different dosage, higher dose may be to appear on the market in the future sometimes of dosage two 3 times. " the development that immunity of gene of Suzhou university president, Shanghai and Xiong Saidong of professor of vaccinal research center ever participated in SARS vaccine, he cited a case to this print journalist. "The manual looks when we take medicine at ordinary times, daily volume 3mg is tagged above some medicine, a gross is added to must not exceed 10mg from the back, when explaining in clinical trial safety is evaluated, dosage had done test according to 10mg, prove be safety. " the group of article of Chen Hui of associate professor of college of major of Taiwan university vet, give out the accept rice vaccine that asks for MERS integratedly in the light of middle east breath at grinding in May 2019, she also tells this print the reporter, in the inject dosage with clinical first phase, the vaccinal dosage when regular meeting appears on the market than vaccine wants tall. "First phase is clinical and main the investigation that makes noxiousness, in the future the person of vaccination, have old person, child, pregnant woman, and the person that has chronic illness possibly, the safe dose that everybody can bear the weight of is different. Although hit larger dose,only vaccine proves be safety when clinical trial, just method uses the public. Just method uses the public..

Expedition is photographed

According to the agreement, chen Mengqiao is injecting vaccine just can remove after 14 days hotel segregation, reside a segregation 14 days again then. Wu Ke says, these act are for can more convenient, accurate observation suffer the person that try the change of level of the antibody inside vaccination rear body, also can prevent to suffer infection of occurrence virus of the person that try. "This is one kind goes to never have what the person has used is brand-new product, in case produce extreme situation, abrupt somebody appears serious and harmful response, also can undertake cure at any time and place. Additional, wuhan just announces to make apoplectic jaws division, volunteer vaccination when, wuhan still is high risk area, after meaning a volunteer to return a society, be affected likely. " Wu Ke tells this print the reporter, vaccinal to these vaccinal volunteer will tell, according to the circumstance they can make antibody, resemble there was guard in an army, once the enemy came, piquet can alert, bring the immune main forces inside body into play to come out to fight, "But if did not appear in antibody, when immune force was not built, be affected, the effect opinion of whole vaccine can become extremely mixed " .

On March 26, the world defends heart of Tan of constituent total a secretary in charge of sth to fill in to answer new coronal in 20 countries group leader pneumonic and special summit expresses on the meeting, new coronal is pneumonic craze is growing with exponential level speed. He is mentioned, amount of case of illness achieves first 100 thousand flower between 67 climate, achieve the 2nd 100 thousand used 11 days, and the 3rd 100 thousand used 4 days, the 4th 100 thousand used 2 days only. Tan heart a place of strategic importance says, if not be all countries,take positive step, millions person may die, this is crisis of a whole world, need the whole world to answer. All over the world under the setting of craze, vaccine becomes the hope that can resolve the crisis effectively most -- more vaccinal than Er and Meilinda Gaicijijinhui have an inoculation and Raj Shankar Ghosh of contagion vice director once had been shared, came 2011 2020, if calculate,go up to prevent the more extensive economy such as death and deformity and social value, vaccinal foundation throws the each dollar of vaccinal charge to will produce the cost redound of 44 times.

American country allergy and Anthony of contagion institute director · blessing on the west

The match of virus of field and one new coronal already open: Virus wants to encroach more people, the mankind wants to protect more people. According to the not complete count of Chinese vaccinal guild, the project of research and development that the whole world has nearly 90 units to develop new coronal vaccine more than 60. Chen Hui article tells this print the reporter, after the pathogen of new coronal virus at the beginning of January is affirmatory, the whole world is being done a few about the experiment with new coronal vaccinal perhaps medicaments. "Before the preparation of biology science and technology, antigen compares ten years etc now better. The energy of research and development of the whole world is in almost 100% investment. " there is official orgnaization already inside this participate in, also have the itch to try after commercial company aims at an opportunity.

On Feburary 1, the researcher reveals process of experiment of vaccinal research and development of MRNA of virus of new-style coronal shape (Shang Yanjun is photographed / people visual sense offers a plan)

"Bo Wosheng content " it is a among them. On January 25, 2020, wu Ke followed enterprise of an United States to sign cooperative agreement namely, become home to announce the earliest to participate in one of 3 orgnaizations that new coronal vaccine studies. Wu Ke tells this publication, be in early actually on January 20, they had had the discussion of cooperative intent book, "Xiaogong's driver makes delicacy of agile, smell, meeting the significance that takes vaccinal research and development for a short while. And big company, especially the respect expression such as economic benefits appears on the market goodly company more is in etc, seeing new coronal epidemic situation how develop next. " Wu Ke says, on January 28, the research team of company vaccine rises with respect to urgent organization. They rise the backbone organization of 1/3, have 30 much people, still took a name, cry " new coronal accuses a group especially " , wu Ke holds the post of captain. Because time is critical, the project did not have groovy project approving flow, "Did not make even the budget, our group is designed with respect to what had technical plan with all one's strength and prove " .

On March 17, annals of Wang Jun of academician of Chinese Academy of Engineering accuses the detailed case that research and development of vaccine of domestic new coronal announced on mechanism press conference in couplet of joint defence of the State Council: Cent of research and development of new coronal vaccine lives to destroy project of vaccinal, gene recombines inferior vaccine of carrier of virus of the vaccine of carrier of virus of unit vaccine, gland, flu that reduce toxin and nucleic acid vaccine 5 technologies direction. These direction, with worldwide the research inside is consistent. Of dominant of Chen Wei of academician of Chinese Academy of Engineering recombine first phase of vaccine of virus of new-style coronal shape clinical trial was obtained on March 16 batch through, it is one of vaccine with expectation at present highest value.

Xiong Saidong tells this print the reporter, recombine vaccine to had been in the immunity of all sorts of people and animal virus disease, bacterium disease and verminosis had much research in precaution, it is method of a kind of traditional vaccinal research and development. "An advantage of this kind of method is technical maturity, do not need specific biology grade lab to be able to do a test, but the biggest question is slower. Want to get the gene of S albumen above all, after having gene recombining, want to apply technical measure to build project bacterium again, in order to convey protein, undertake to its rarefied, assistant agent conpatibility of medicines should follow later, ability forms vaccine. Recombined gland virus vaccine to use similar technology, go to purpose gene clone in gland virus carrier, use gland virus to send purpose gene inside the cell, convey corresponding antigen and induce the protection immunity of airframe. Before domestic researcher has, dust rich plays the vaccinal research experience such as virus, its research and development is mixed from maturity of fundamental technology theory, technology for the circumstance of clinical trial, each respect is more mature, can enter clinical trial more quickly so. Can enter clinical trial more quickly so..

As same as Chen Wei day, moderna company of the United States announces to already developed vaccine of MRNA new coronal that day clinical trial. Moderna company is one of tycoons with MRNA vaccinal the oldest technique. This vaccine arrives from choice alignment first human body experiment spent 63 days only, it is one of vaccine with the at present rapiddest progress. American country allergy and contagion institute and Moderna company together, develop vaccine of MRNA new coronal jointly. Virus of card of stockaded village of this institute research helps the illness such as virus with dust rich, still led worldwide inside the research that waits for a disease to AIDS, tuberculosis, malaria and allergy. Place Chang'an east Ni Fuxi (Anthony Fauci) accepting when interviewing, say, this new research " roll out with record-breaking speed, it is the important the first step that achieves this one target to be stridden forward " .

Moderna of company of American biology science and technology is located in the lab of city of Cambridge of city of Ma Sazhu a place of strategic importance. Already successful development goes Moderna in the light of the human body vaccine with new pneumonic coronal, already sent the first batch of vaccine to security of open of academy of American country sanitation clinical trial (photograph on Feburary 28)

In the mankind in vaccine history, MRNA vaccine can say is " young one generation " . MRNA is a kind of nucleic acid member that carries hereditary information, it is the intermediate measure that shares DNA transcribe and protein to generate, the measure that synthesizes albumen first with traditional vaccine is different, xiong Saidong tells this publication, MRNA does not need to obtain virus or virus are relevant protein directly, use purpose gene to be able to produce the nucleic acid that has genetic code (medicaments / vaccinal) , the cell that indicates human body oneself synthesizes certain protein, will cause immune reaction, it is speed of research and development a way with very new line of faster, technology. "Be in the United States, the technical reserve of MRNA vaccinal respect has matured quite, but home still has a few difference, need is overcome and many technical difficulty and bottleneck are solved, the phase of research and development with domestic so vaccinal MRNA is mature to platform technology destroy live vaccine, recombine gland virus vaccine to wait, studying progress is slow. Studying progress is slow..

Jenny of 43 years old Fu Hale (Jennifer Haller) the first healthy participator that is this experiment, she scatters permanent institute in Xiyatu's Kai - the research center accepted Washington state vaccinal. This second it is two agents vaccine medium potion injects, this vaccine will be removed a month injects again. Be over in inject after vaccine leaves inject room, with a ha strap to associated press to express, "Feel helpless when our everybody when, to me, this is a very good chance " . According to the report, will 45 ages are in 18? 55 years old of healthy volunteers between participate in vaccination. The purpose of this one experiment is affirmatory code name the vaccine that is MRNA-1273 is effective -- whether can vaccine cause immune reaction, and whether can gives dose cause undesirable side effect.

Fu Hale is in Jenny of 43 years old of Xiyatu triumphant Sa Yongjiu institute - the research center accepted Washington state human body vaccine experiments

Although progress is the rapiddest, but the problem that a lot of people worry about to MRNA-1273 follow-up may appear. Xiong Saidong says: "MRNA vaccine research and development of a few years comes to nearby look, the technology of a few keys still has bottleneck. Those who be like MRNA is transmissive with the interpreter, how to send MRNA effectively go inside the cell, transmissive after going in, how does effectively interpreter come out, it is existent technical difficulty. " on the other hand, because of time problem, MRNA-1273 feeds approval of medical inspect bureau to fall in the United States, jump over animal experiment to enter clinical first phase to experiment directly. "Clinical before the animal experiment of research, need evaluates each parameter carefully, say the animal is vaccinal for example after vaccine, can be you protected really? The first day of generation what change, have what change the following day, these metropolises affect the reaction with follow-up clinical human body directly, little animal experiment goes the word of test and verify, be some adventure of course. " Chen Hui article says to this print journalist.

No matter be to recombine vaccine of gland virus carrier or MRNA vaccine, it is a kind of way of vaccine of research and development only, the distance can appear on the market use still have very long distance. Look from the history, vaccine arrives from research and development appear on the market to be able to experience long time normally. The most outstanding example is AIDS vaccine -- obtained 1982 batch begin to develop, experienced time of 38 years to now, still appear on the market without vaccine.

A vaccine is effective, which kind of can go up really battlefield, need follow-up farther test and verify. After this includes first phase two period clinical trial. Experiment at clinical first phase relatively, 2 period clinical should examine large-scaly security and effectiveness, 3 period it is more large-scale effectiveness and stability test. Chen Hui article says: "The first phase of traditional vaccine is clinical need a few to suffer the person that try probably, time of about one year is finished. Will tell commonly, clinical trial jumps over in the future, need to throw more time, manpower and funds more, the difficulty that face is greater also. " Chen Hui article tells this print the reporter, clinical 2 period, 3 period scale is larger, involve hundreds person, thousands of person possibly suffer the person that try. The experiment should undertake double blind contrasts, a group of vaccinal virus are vaccinal, a group of have an inoculation comfort an agent. During this, every suffer the person that try to opportunity bring into contact with infects a source, in this one process, need observes whether the person of vaccinal virus vaccine can obtain protection. The analysis of the person that try to sufferring only, and all sorts of problems that during solving, appear, the time that needs 3 years two at least. "After vaccine appears on the market, covers range may be person of millions of people, a few ten million, more even, be in so evaluate on the meeting is more rigorous. " Wu Ke tells this print the reporter, to popular contagion vaccine, normally 3 period clinical the test that should pass two popular s surname -- if disease a year once fastigium, make a popular season, if have one year twice, make two popular season.

In addition, clinical early days still faces many problems. Above all, vaccine should act well, of new coronal virus " highly candy radical changes an appearance " it is one of problems that should solve. By virus heredity material and protein crust comprise virus, the suffers infection cell that protein crust can lap virus heredity material is secreted, go again " invade catch " new healthy cell. Relying on this protein crust, virus ability lives. The protein that 50% exceed inside the cell decorates catenary having sugar, they were participated in include become divided of cellular identifying, cell, development, signal to turn guide, immunity is respondent all sorts of significant life activities that wait inside, this process is called " candy radical is changed " . Change and of character, of virus duplicate and to host inbreak to matter with this one process. On March 25, institute of Oxford candy biology achieves institute director Raymond Dwek to teach alive bound tip stimulative center of library of the intelligence in scientist association Shanghai and industry of science and technology of Shanghai biology medicine sponsors jointly " pestilence of war of science and technology " point out on seminar of the international on the line, new coronal virus is put in height the characteristic that candy radical changes, this meeting makes poison of go to the bad undertakes a variety of mutation, bring huge difficulty to vaccinal research and development. "The candy of HIV base change 3 the dot is flu virus? 6 times, this also is later one of main reasons that vaccinal research and development cannot succeed tardy. And the candy of new coronal virus base change at least 2 times the dot is HIV virus. " Raymond Dwek says.

Group of Chen Hui article is making the development of MERS vaccine all the time, she says to be in enter clinical before, the lab considered to had spent many time. "For instance, exterior protein should choose which paragraph of element that serves as vaccine after all, want after all complete paragraph still be half paragraphs protein gene, still want the most important that part only. Later, is the surface protein after all the antigen sex of which one part is best be also the safest? Each paragraphs antigen makes a likelihood be about 3 months. If,this is meant at the beginning set 3 kinds of antigen, we are in 9 months in front the production that does antigen and test. And take truly, after affirmatory good antigen, the part of vaccinal assistant agent, should want to put how many amount after all, also want to do on dosage of a lot of optimize. " Chen Hui article tells this print the reporter. Besides, lab phase still has other and many job, infiltrate vaccine for instance inside small mouse system, "Want to pass 300 days, wait for 10 months, ability sees its antibody can last really quite so long, it is short-term and effective, long-term still and effective, among these raise charge to wait a moment very much. We are 4 years above this project, place is in probably with funds RMB 1.1 million to 2.5 million yuan between. Next the target is body of monkey, orangutan is like in large animal aspirant travel experiment, this needs more investment, still applying for funds at present. Still applying for funds at present..

To new coronal vaccine, research and development of prototype of even if vaccine comes out, arrived animal experiment phase, the likelihood still can encounter the problem that cannot find appropriate animal model. Wu Ke tells this print the reporter, it is with vaccine of new coronal virus exemple, virus attack person is through ACE2 this accepts put oneself in another's position, and small rat accepts put oneself in another's position without this. What use health that is to say is normal small rat has a test, the animal won't produce as similar as the mankind pathology to react. Turn with respect to need at that time gene small rat, put ACE2 gene in the gene of small rat namely, let small rat also have ACE2 to accept put oneself in another's position, come so, when coronal shape virus atttacks small rat, it just can appear with the mankind's similar symptom. Many experts are mentioned, because of epidemic situation reason, wuhan turns gene small rat is rare be short of, place has turn the animal lab of aptitude of gene small rat, the group that waits to do animal test has been discharged removed cue.

Although at present has 60,the project of research and development of vaccine of many new coronals is undertaking, but a lot of people are afraid, whether can resemble 2003 " SARS " same, if epidemic situation disappears, consider to be able to stop.

The igneous enthusiasm scene when SARS vaccine is being developed before Xiong Saidong thinks of 17 years via regular meeting. All circles of various at that time government, society and researcher's vaccinal to SARS research and development takes seriously highly and advance actively. "National science foundation appoint, committee of science and technology of ministry of science and technology, Ministry of Education, Shanghai, Fudan University start all sorts of project fund for a short while, be short of money to give money, want what condition what to give the condition. " Xiong Saidong is recollected to this print journalist, 2003, common project of a research and development, average outlay about 200 thousand yuan, can you use 3? 4 years, but the item that makes SARS vaccine consider at that time, have 500 thousand yuan rarely the following, this is in at that time is the funds with very big brushstroke.

The enthusiasm of enterprise of science and technology is very tall also. 2003, p3 lab (biology safety defends 3 class lab) very little, there is limited company of a biological product is in Shanghai. Xiong Saidong follows the other side to contact, answer of the other side is very straightforward, "It is OK to use any equipment, installations " . Later, this company lives to develop SARS to destroy with all one's strength vaccinal, stop for a time advocate the vaccinal product line of business Wu. Try hard nevertheless and throw as the die of SARS epidemic situation phase out. After SARS ends, the government adjusts vaccinal research and development from lash-up condition for common position, the country also makes clear a regulation at that time, do not have the general lab of corresponding condition, forbid to contact virus again.

The union of all sorts of elements makes SARS vaccinal research and development stopped. Xiong Saidong group completed the vaccinal development of lab phase, stop in clinical the animal experiment phase before. Beijing division promotes a company to be in continuously below the circumstance of deficit, live at finishing SARS to destroy in December 2004 vaccinal first phase is clinical research, also stop finally in first phase clinical phase. "Enterprises of a lot of vaccinal research and development are in for many times urgent the loss that answered the process of epidemic situation to assume oneself, after this, a lot of big companies become more careful, encounter similar issue, can hesitate first wait-and-see. " Wu Ke says to this print journalist. He still mentions additionally two things, 2009, flu craze did not resemble anticipating kind serious, numerous country refuses to already the flu vaccine that the enterprise orders pays; Dust rich pulled epidemic situation to break out in Africa 2014, numerous pharmacy company participated in dust rich to help vaccinal research and development, because epidemic situation is controlled later, the vaccine that is come out by development is approved till what epidemic situation appeared to just obtain the United States to superintend a branch again 2019.

"Shed vaccine of travel degree research and development according to the disease, this one practice is improper. " Chen Hui article says, "We know new coronal virus follows SARS now is most resemble, the their very much mechanism that cause disease special also picture, to the understanding of SARS extensive sex, conduce to us present vaccine follows medicaments research and development. But more regretful, the SARS vaccine research before is not quite sufficient, after we do not know SARS vaccine continues to advance clinical trial, have what result. This the research of scientific aspect also does not have too much experience to be able to be used. " He Chenhui language is same, many experts put forward, the vaccine that should build a nation lays in a system.

Be in " informal discussion of committee member of the Chinese People's Political Consultative Conference of delegate of National People's Congress of 2019 medicine bound " on, feeling vaccine is Kang Yiliu of Chang'an of trustee of Inc. of project of Hua Lansheng content exemple, put forward to want to build country of national flu vaccine to close store mechanism. World Health Organization announced vaccine of flu of the Northern Hemisphere every year to produce poisonous individual plant Feburary, manufacturing company buys poisonous individual plant and standard items to relevant orgnaization according to having a case, poisonous individual plant does not have a change, can plan production instantly, if poisonous individual plant produces change, need to buy poisonous individual plant and standard items from abroad afresh; Is flu vaccine made up from production of raw material preparation, former juice, finished product, does courtyard of the check in sending approve autograph calibrating does full cycle need 5? 7 months. In good health mention, home executes flu vaccine at one's own expenses vaccinal policy, vaccinal rate is insufficient 2% , cover the key multitude that needs have an inoculation more impossibly, once have epidemic situation, the place of crowd focusing if the school is incidental eruptive, increase epidemic situation further diffuse, bring about epidemic situation to spread. If this moment purchases vaccine again, because flu vaccine is seasonal strong, production examines periodic and longer, often far water cannot save close thirsty.

Wu Ke feels, of mechanism of vaccinal development, reserve build need society the support of each respect. Even if this new coronal is pneumonic disappeared, the country also should want to had done vaccinal reserve work, in case next time recurrent similar case. "This produces tent like us same, aseismatic tent is not after saying the earthquake came, we produce a victim to use temporarily, however the country must lay in some of tent, once have earthquake, big calamity, go to tent v immediately, this system must be built. " and college of medicine of Shanghai traffic university is postdoctoral Yu Dong expresses when accepting media to interview, national vaccine lays in a system to should include at 2 o'clock, "It is reserve vaccine, it is the ability that lays in manufacturing vaccine another bit, among them more important at 2 o'clock. To prevent large epidemic disease, should have plan as a whole strategically, have good technical platform, can apace manufactures this vaccine, ability is answered quickly " .

(the article carries formerly " triplex life weekly " 2020 the 14th period)

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