As the constant change of modern people lifestyle: Physical labor decreases, high quantity of heat, tall adipose food intake is overmuch, diabetic had made disease of a kind of tall hair now, and diabetic happening appear young turn a tide. Got diabetic, most person may eat with respect to need fall candy medicine, a lot of person concern fall the side-effect of candy medicaments, have what effect to liver kidney especially, for instance the reader asks I eat 2 armour double guanidine for a long time to have poisonous side effect to liver kidney, I introduce a kind of profess to convinced with the most commonly used diabetic to fall today candy medicine has to liver kidney without the influence. Current and clinical on use the most extensive profess to convinced to fall candy medicine is double guanidine kind medicaments, be like 2 armour double guanidine, it is with this medicine is a foundation normally, can use alone already, also can combine other fall candy medicine.
{! - - PGC_COLUMN- - }2 armour double guanidine falls as a kind of classical profess to convinced candy medicine, there had been 50 old histories in clinical application, it is to use the most extensive profess to convinced to fall one of candy medicine. Because its fall,candy action is made clear, side effect is little, and clear heart and vessels protects action, it is so 2 model diabetic a gleam of uses drug. Whether is double guanidine damaged to liver kidney about 2 armour, we can see 2 armour double guanidine how does consensus of clinical application expert say: 2 armour double guanidine does not metabolize through liver, think 2 armour double guanidine does not have hepatic noxiousness so.
Current, not complete patient uses liver function 2 armour double guanidine is clinical the data is less. But the cleared ability that serious damage meets liver function restrict lactic acid apparently, when proposal transaminase is so taller, serious perhaps liver function not full-time, had better not use 2 armour double guanidine. Spend gently in transaminase 2 armour double guanidine is used to need to monitor liver function closely when lifting.
2 armour double guanidine affects to the kidney: 2 armour double guanidine is main with prototype from the eduction in make water, cleared and rapid, 90% above can keep clear of in the day, , cleared rate is its kidney flesh anhydride is 3.5 times of rate more cleared, itself was not damaged to the kidney. Research shows 2 armour double guanidine still has certain kidney to protect action.
But have when kidney function itself when damaging, meet those who affect 2 armour double guanidine excrete, the likelihood brings about 2 armour double guanidine and lactic acid to be in body cohesion collect. So 2 armour suggest in the relevant guideline of double guanidine application, 1.73 ㎡ of · of <30ml/(min of rate of filtration of patient kidney spherule) moment avoids to use, cleared rate is in kidney 1.73 ㎡ of 30-60ml/(min · ) can decrease a quantity to use, be more than 60 when need not adjust dosage.
