This column leaves sick at heart of high make water for everybody introduction to healthy the harm that each respects cause.
If be not controlled for a long time,a lot of friends know high make water is acerbity can bring " gouty " problem, but actually, not be acid of all high make water hematic disease patient can break out gouty, in acerbity crowd of high make water, the multitude that also only about 10% is control can break out gouty. So since odds is so low, regard a high make water as acerbity patient, inside the person that I can fall very likely in that part of 90% not to send pain wind, am then I still necessary to control acid of high make water? Why does the doctor still exhort again and again should control acerbity standard of good make water?
Because acid of high make water is endangered to the health of the body,this is, can be to may cause gouty show effect not just so simple.
Acid of high make water is the biochemical foundation that causes gout and the directest pathogeny, but high make water is acerbity besides can cause acute gout beyond fit, send made gouty issue for a long time repeatedly, still can make progress gradually for chronic gout, form chalkstone finally even, affect articulatory function and body activity, arthritis of chronic and gouty sex, not only the destruction that can cause joint, cause nephritic pathological change possibly also at the same time, make kidney function is damaged, the problem that causes kidney function exhaustion even appears.
Disease of acerbity blood of high make water is endangered to the health of the body, ask besides what bring about the respect such as urgent chronic gout, chalkstone beyond, acerbity level of the make water in blood is long-term on the high side, still can promote oxygen freedom radical is formed, cause loss of hemal endodermis cell; Still can promote one oxidation nitrogen to add up to enzymatic expression at the same time, bring about hemal easy to shrink of the function maladjusted; The friend of problem of fat of tall to having blood, exorbitant uric acerbity level can quicken the oxidation of cholesterol of low density lipoprotein to decorate, quicken sclerosis of arterial congee appearance; At the same time acid of high make water still can damage function of line bead body, dissolve enzymatic form, the wither that causes cell of kidney canaliculus endodermis and cell of heart cardiac muscle dies, accordingly, acid of high make water causes gout, it is a respect that it forms healthy harm to the body only, and acid of long-term high make water is not controlled, can wait for many organs to cause healthy harm to the heart of human body, head, kidney --
1.Acid of high make water and hypertensionWhen the uric acid inside human body the level is in normal health when limits, uric acid is normal to human body the it is main to maintain a move physiology function of blood pressure, but when uric acid the level lifts, tower above is normal when limits, can form bad influence to blood pressure.
Acid of high make water is the independent risk element that causes high blood pressure. Research data shows, uric acid value every are elevatory 60 μ Mol/L, come on hypertensively the risk can increase 13% . And animal experiment discovers, when the acid of blood in the urine of bandicoot the level is in 7 Zhou Neisheng is tall when 96 μ Mol/L, the level that its systole approachs rose the level of 2.2mmhg, if give,fall uric acerbity medicaments, say acid of blood in the urine to reduce, criterion blood pressure won't lift. Acid of high make water can affect level of influence blood pressure, those who cause blood pressure is elevatory, hypertensive perhaps control hard, when as acerbity as make water level is exorbitant, the easy that can affect blood-vessel shrinks function, kidney element still can activation in the meantime - hemal and nervous element - system of aldehyde solid ketone about.
Accordingly, to hypertensive patient, if accompany the problem that has sick at heart of high make water at the same time, may appear to control the problem of blood pressure harder, on the choice of depressor content, the diuretic with elevatory acid of stimulative make water should avoid to use as far as possible, and the general benefit of depressor of system of ketone of solid of kidney element aldehyde or Sha Tan kind medicaments, it is better choice, potassium action has chloric Sha Tan to fall distinctly the depressor of uric acerbity action, also be hypertension incorporates the medicaments that acerbity patient of high make water can choose.
2.Acid of high make water and metabolization are asked for integratedly
{! - - PGC_COLUMN- - }Metabolization is asked for integratedly (MS) a general designation that is a group of diseases that are a feature mussily with integrated metabolization. Metabolization is asked for integratedly resist with insulin normally closely related, insulin is counteractive not only can bring about blood sugar metabolization is disorder, same insulin resistance also can affect the metabolization of acid of blood in the urine, on one hand the production that it can affect acid of blood in the urine, those who bring about acid of blood in the urine to generate is overmuch, and human body drops to the sensitivity of insulin, the insulin that can make the exudation of sex of body acting countervail overmuch, tall insulin can affect nephritic kidney canaliculus, bring about kidney canaliculus to absorb grow in quantity acerbitily to make water again, those who weigh absorption grow in quantity to be able to bring about uric acid to excrete is opposite decrease, those who cause uric acerbity level is elevatory, accordingly, metabolization solicits the patient of the problem integratedly, can have the problem of the many respects such as fat of acid of high make water, tall blood, tall blood sugar normally.
And of acerbity level of blood in the urine lift the incidence of a disease that also imposes integratedly with metabolization shows disease relevant, acerbity level of blood in the urine is less than the metabolization of 360 to impose occurence rate integratedly for 18.9% , and the occurence rate that acerbity level of blood in the urine imposes integratedly in the metabolization between 360~420 is as high as 36.0% , and when acid of blood in the urine the level is more than 600 when, the incidence of a disease that metabolization imposes integratedly is as high as 70% above. Want to reduce what metabolization asks for integratedly to produce odds, still should have controlled fat, control weight index and waistline inside normal limits, the friend of problem of fat of tall to having blood, also want to note the control of hematic fat and improvement.
3.Acid of high make water and 2 model diabeticHave the friend of acerbity problem of high make water, also be at the same time 2 model the Gao Wei crowd of the diabetic, acid of high make water is 2 model the independent risk element of the diabetic. 2 model come on diabeticly risk as acerbity level of blood in the urine lift and lift gradually, a home considers to discover, of acerbity patient of high make water 2 model diabetic come on risk, relatively uric acid is normal person come on the risk increases 95% above; And another research shows, every add acid of blood in the urine 60, new hair 2 model come on diabeticly the risk increases 17% .
Acid of high make water appears easily to send diabetic issue newly, this and acid of high make water produce be closely bound up with what insulin resists, because of the patient of problem of disease of acerbity blood of this high to having make water, controlling good hematuria acerbity standard, reduce gouty risk while, also want to notice the monitoring of blood sugar is measured, this and can as early as possible discover damage of hollow blood sugar, candy is able to bear or endure the amount is unusual wait for symptom of diabetic early days, as early as possible give interpose and control.
4.Acid of high make water and cardiovascular diseaseAcid of high make water also can affect the health of cardiovascular respect likewise, whether to have acerbity problem of high make water, also be forecast cardiovascular disease risk with the main factor that forecasts cardiovascular mortality. Do not control acid of blood in the urine is exorbitant and for a long time, acerbity chroma of exorbitant blood in the urine can quicken the wither of cardiac muscle cell to die, still can injure hemal endodermis cell, accordingly, acid of high make water is one of risk elements that bring about arteriosclerosis, and element hind waits in fat of corrective age, sexual distinction, hypertensive, tall blood, diabetic, smoking, the cardiovascular incidence of a disease of patient of disease of acerbity blood of high make water is normaller than acid of blood in the urine the patient is tall 9% , to having patient of coronary heart disease, amalgamative the patient mortality of acid of high make water increases 16% , every raise acerbity level of blood in the urine 60, the dead risk of coronary heart disease increases 12% , and the effect of female patient is more distinct.
And acid of high make water is occurrence heart declines likewise, the independent risk element in be short of soldier of head of courage and uprightness, consider to discover, reduce acid of blood in the urine to be able to improve the left ventricular function of blood stream of coronal arteries and veins and outspread core myapathies significantly, reduce heart and vessels of hypertensive nephrosis patient to reach complete the risk because of death.
5.Acid of high make water and nephritic system are healthyMake water lifts acerbitily, especially acerbity problem of high make water, can cause the disease of the respect such as nephrosis of acidity of nephrosis of acidity of acute make water, chronic make water, kidney stone, uric acerbity on the high side can bring about kidney small artery to bear for a long time to be affected hypertensively, the endodermis cell health that also can injure nephritic blood-vessel at the same time is concerned, additional, long-term high make water is acerbity, the crystallization of uric acerbity salt can form deposit in joint position not simply, also can be in likewise nephritic place deposit, cause the kidney stone of uric acidity, all sorts of nephrosis problems, additional, consider to discover, acerbity patient of high make water produces the odds of chronic nephrosis, diabetic nephrosis to also increase significantly, and survival rate drops significantly.
Closely related disease of acerbity blood of high make water and kidney function health, acid of high make water can affect nephritic health, and what kidney function can not cause uric sick at heart again completely is farther elevatory, accordingly, want to protect good kidney health, should control acerbity standard of good make water first, uric acerbity level is only normal, nephritic health just can have safeguard.