Libaweilin or benefit cling to " violate " forest?
Author ｜ Wang Sheng is become
Libaweilin abuses a problem is platitude, common occurance already actually, a lot of people however because of by the wrong idea of first impressions are strongest " embedded " cerebrum is confirmed and " make repeatedly do not change " .
Libaweilin all the time with a few " false honor " numerous common people and rife cure protect becloud and trickily personnel. Though Libaweilin is bane of wide chart disease-resistant, and the virus that is used inside human body to basically be aimed at cure actually is very finite; Libaweilin is called " virus Zun " , and below most circumstance however cannot virus " defeat " , side effect is quite big still; Turn over a dictionary, we know those who violate to Wei is first word, libaweilin is returned in reality is really " benefit cling to ' violate ' forest " -- obtain " benefit " benefit is dry " cling to " , abuse " violate " be like,use " forest " .
This is not exaggerate sth just to scare people really, we chat today through authoritative evidence.
Common error one: Libaweilin is used at treating common cold
Active the 8th edition " internal medicine learns " (published 2013) teaching material affects disease-resistant poison in acute the upper respiratory tract write to in cure " still do not have content of bane of disease-resistant of specially good effect at present... Libaweilin and, add up to afterbirth virus to wait to flu virus, deputy flu virus and respiratory tract have stronger inhibition, can shorten course of diseases " . Of the 8th edition " pedology " teaching material is written in infection of acute the upper respiratory tract " hold thing of bane of inchoate application disease-resistant, usable Libaweilin (virus Zun) , dosage is 10 ～ 15mg/ (Kg · D) , profess to convinced or vein drop are noted " .
Look from teaching material, although do not have content of bane of disease-resistant of specially good effect, but inchoate still can apply Libaweilin. Authoritative teaching material so said, can you still be misapplication?
Wait a moment, look downward please.
Everybody knows, the content of teaching material is some lag, and what a lot of moment tell is not very fine, let a person " know its like that " , but it is clear to was not told " like that " .
The cause of disease of common cold learns with nose virus the commonnest (30% ～ 50% ) , it is coronal shape virus next (10% ～ 15% ) , respiratory tract adds up to afterbirth virus (5% ) , deputy flu virus (5% ) , gland virus (＜ 5% ) with enteroviruses (＜ 5% ) etc.
Libaweilin gets used to disease respect to point out clearly in inject fluid manual is " those who be used at respiratory tract to add up to afterbirth virus to cause is pneumonic and bronchitic " , the manual of tablet of benefit Ba Weilin and grain the form of a drug is getting used to disease respect to write to be able to be used at more than inject fluid " skin herpes virus is affected " , all did not tell can use at common cold.
Note respect all emphasizes particularly " unfavorable the patient that is used at adding up to afterbirth virus to affect for respiratory tract without lab diagnose " , " Chinese pharmacopoeia is clinical the notice that use drug (2015 edition) " also be to emphasize so.
In other words, libaweilin basically is those who be used at treating respiratory tract to add up to afterbirth virus to cause is bronchitic and pneumonic, not be common cold; Libaweilin is not content of bane of disease-resistant of so called really wide chart (the experiment outside body can be wide chart, but use evidence is not being had at present inside human body is wide chart) , virus sort is various, and it basically just is used at treating respiratory tract to add up to afterbirth virus to affect, and the commonnest virus that this virus is not common cold.
If be respiratory tract to add up to afterbirth virus without lab diagnose infection and not be the person that respiratory tract adds up to afterbirth virus to affect, and Ba Weilin treats applied benefit to be belonged to commonly exceed a manual to use drug.
" the expert consensus of make a diagnosis and give treatment of common cold standard " and " common cold standard uses special multitude expert consensus of medicine (2015) " all think, "Common cold is be restricted oneself sexual disease, with be being given priority to to disease cure, need not use disease-resistant poison to medication, content of overspend disease-resistant bane has the risk that increases relevant and harmful response apparently " .
If want to use, in the disease-resistant bane matter that can consider to apply, mention enzymatic depressor of nerve ammonia acid or retarder of ionic passageway M2 relevant medicaments, and do not say a single word to Libaweilin and this kinds of medicaments -- that is to say, did not recommend use Libaweilin.
" common cold standard treats Chinese children expert consensus (2013) " in in fighting virus to treat, also be not to carry Libaweilin, but about the pathogeny cure has write: "Ba Weilin of inchoate application benefit enrages course of diseases ministry of nose pharynx of mist agent gush may have certain profit [12] " , this word looks be like supportive benefit Ba Weilin to enrage mist agent to be used at common cold, can examine the place place to tag actually [12] bibliographical reference is afore-mentioned " the expert consensus of make a diagnosis and give treatment of common cold standard " , this article does not have Libaweilin's word at all from A to Z.
Of World Health Organization " use medical list basically " all do not recommend use Libaweilin to treat common cold with the medicaments manual of American food and medicaments management board.
Anyhow, common cold does not suggest to use disease-resistant bane thing, if want to use, both neither first selection also does not recommend use Libaweilin.
Common error 2: Libaweilin is used at treating a grippe
The grippe is the infection of respiratory tract of a kind of acute that causes by flu virus.
" consensus of expert of grippe of treatment of thing of ill bane of cold of sex of travel of rational application anti-current (2016) " in write to " the experiment outside body shows Libaweilin has anti-current, but the serious and harmful response as a result of Libaweilin, clinical the research data that treats flu about Libaweilin is less, and does existing most research show Libaweilin treats inaccuracy of flu curative effect to cut " -- what meaning is this? The meaning does not have evidence to explain body a person operating from within in coordination with outside forces uses Libaweilin at present namely effective to flu, and side effect is big, do not suggest to use.
" content of ill bane of cold of sex of travel of rational application anti-current treats grippe expert consensus (2016) " , " children flu is diagnosed with remedial expert consensus (2015 edition) " , " plan of grippe diagnosis and treatment (2018 edition) , do not have Libaweilin, 3 authoritative data are pair of Libaweilin and this kinds of medicaments does not say a single word more after.
Accordingly, do not recommend Libaweilin to be used at the grippe.
Common error 3: Libaweilin is used at children acute to affect sexual diarrhoea
Children acute affects the pathogeny of sexual diarrhoea to be virus to affect more, with annulus shape virus, Nuo if virus is most common.
Learned group of chemistry of pedology branch disappear to make by China cure 2016 " disease of diarrhoea of sex of infection of Chinese children acute is clinical practice guideline " point out clearly, still do not have at present fight virus medicaments in the light of what cause infection of gastric bowel path, the treatment that refuses ill poisonous at acute diarrhoea disease applying does not have evidence, do not recommend application.
" pyretic: Sang Fude fights microbial cure guideline (2016 edition) " also point out, baby and children diarrhoea do not recommend disease-resistant poison to treat medicaments.
This shows, libaweilin need not affect sexual diarrhoea at children acute.
Common error 4: Libaweilin is used at the groovy cure of brothers mouth disease
" epidemiology " (the 8th edition) brothers mouth disease is paragraphic learn cure to have about cause of disease write, "Still lack distinctive, efficient disease-resistant bane substance at present, but take into consideration the circumstances chooses Libaweilin to fight virus to treat " .
Active teaching material " pedology " (the 8th edition) brothers mouth disease is paragraphic in, no matter be exemple of general common fault or serious illness case of illness,all did not suggest to fight virus to treat, do not have more allude Libaweilin.
Guideline of diagnosis and treatment of disease of mouth of our country brothers and American disease accuse a center to release brothers mouth disease to all did not allude treatment of disease-resistant bane thing.
But, disease of mouth of brothers of our country Ministry of Public Health is clinical expert group released 2011 " enteroviruses 71 model (case of illness of EV71) infection serious illness is clinical cure expert consensus " point out, still do not have at present exact and effective fight EV71 virus medicaments, libaweilin tries fact of test and verify to have outside body restrain EV7l to duplicate to destroy with the part live virus action, can consider to use -- but that is serious illness case of illness.
This shows, the disease-resistant bane thing that includes Libaweilin inside is used at treating brothers mouth disease to lack enough sufficient abide card medicine evidence, cannot serve as groovy medicaments. Unless little patient symptom is heavy, considering brothers mouth disease to have one share also is cause by EV7l, balance benefit is more than the circumstance of fraud to fall, can consider to consult this consensus uses Libaweilin to treat.
Common error 5: Injection uses Libaweilin at pulverization to treat
Article of a popular science has been written before me " inspiratory cure often does pulverization, and these " mist area " in " error " , do you know? " inside cited a few important guides and expert consensus, among them " pulverization sucks person therapeutics to apply expert consensus mediumly in breathing disease (2016) " point out clearly, the medicaments that is not pulverization preparation cannot achieve pulverization grain requirement, cannot keep clear of through respiratory tract, the likelihood is in lung deposit, raise the occurence rate that lung influences thereby; Preservative is contained in vein preparation, wait like phenolic, nitrite inspiratory hind can cause asthmatic show effect.
Replace pulverization preparation to use with vein preparation belong to exceed a manual to use drug, it is unreasonable even with medicine, add the account such as disease-resistant poisonous chart of Libaweilin and its side-effect, do not recommend use Libaweilin so inject fluid turns treatment with Yu Wu.
Below what circumstance can be Libaweilin used?
Although Libaweilin is done not have so be infinitely resourceful, but also not be to be not had can, can use at the following cure:
1, the virus sex that respiratory tract adds up to afterbirth virus to cause is pneumonic with bronchitic patient.
2.Skin herpes virus affects a patient.
3.Gas mist agent can use Libaweilin at virus of conjunctivitis of virus sex rhinitis, angina, pharynx or buccal pharynx ministry to affect.
4.Brothers mouth weighs disease case of illness illy.
5.Epidemic haemorrhage is hot.
6, as chronic as interferon combination therapy third hepatitis.
7, adult hives (children hives need not) .
Manuals of before 3 medicines and chemical reagents that get used to disease basis to come from home (domestic the form of a drug is various, get used to disease endless also and identical, here differ one enumerate) , the 4th gets used to disease thereinbefore to also had been stated, the 5th gets used to what disease comes from World Health Organization " use medical list basically (2013 edition) " with our country " the country fights microbial cure guideline (the second edition) " , the 6th gets used to disease to come from World Health Organization " use medical list basically (2013 edition) " , and of our country " collect of Chinese country prescription (2010 edition) " and " guideline of AIDS diagnosis and treatment (2015 edition) " , the 7th gets used to disease to come from " the country fights microbial cure guideline (the second edition, 2017) " .
Libaweilin from " bright red big violet " become " star living energy of life " , basically be the development as medicine and discovery -- modern medicine pays attention to exquisite evidence particularly, especially the sufficient evidence of curative effect and safe respect, because action mechanism of Libaweilin still is not clear about completely, this medicine is content of bane of wide chart disease-resistant, but that is relative to the experiment outside body character only, and the clinical effect that is used after human body lacks enough evidence, the virus chart that can treat is very few also, and in clinical applying, discover its side effect is bigger.
Accordingly, total bureau of supervisory government of national provision medicines and chemical reagents (CFDA) before the security problem of the harmful response information that still is not aimed at Libaweilin especially undertook a bulletin, exposure its a variety of harmful response, mix to reproductive noxiousness especially haemolysis sex is anaemic.
Be in China, libaweilin has inject fluid, tablet, lozenge, capsule agent, dispersive piece, grain, bubble vacates mist of solution of grain, profess to convinced, gas nose fluid of agent, gush agent, drop, drop eye fluid, eye creams etc more than 10 kinds, phyletic and various, multifarious. Be in the United States that develop, libaweilin has profess to convinced only (tablet, capsule and solution) with pulverization inspiratory the form of a drug of two kinds of ways that use drug, wait for other the form of a drug without inject fluid.
FDA (American food and medicaments management board) approval gets used to card with what Libaweilin treats very little also. Pulverization the form of a drug is approved only spend next respiratory tract infection again with what cause at treating respiratory tract to add up to afterbirth virus, especially the infection of the premature, inpatient that has lung foundation disease. The form of a drug of profess to convinced approves associated interferon to use treatment jointly only chronic third hepatitis (use alone invalid) .
Some people say FDA also approves the form of a drug of profess to convinced to be used at epidemic haemorrhage heat, so I consulted designedly the English manual of the form of a drug of profess to convinced such as the tablet of benefit Ba Weilin that FDA approves, capsule, solution, all did not see have write can use at epidemic haemorrhage heat, but of World Health Organization " use medical list basically (2013 edition) " with our country " the country fights microbial cure guideline (the second edition) " have tell.
Additional, be worth what carry is, the Libaweilin that FDA approves is written in tablet manual " Libaweilin piece the security that remedial gland virus, respiratory tract adds up to afterbirth virus, deputy flu or flu virus to affect and effectiveness have not decide, because of this Libaweilin piece do not apply at these cure " -- the common cause of disease that these virus are the disease such as common cold, flu.
Note
■ before applying Libaweilin to begin, mix during cure at least 6 months after stopping drug, no matter the male or female, all should use contraceptive; If must use Libaweilin, answer to confirm oneself have not be pregnant first; The men and women of equipment pregnancy, should avoid to use Libaweilin; Pregnant woman and its spouse all should ban the Baweilin that use profit; Do not recommend lactation woman to take Libaweilin.
Baweilin has benefit to be sent apparently not only abnormal and the noxiousness that kill embryo, still can cause apparent valve laying seed chroma of atrophic, spermatozoon is reduced and configuration is unusual, and Libaweilinke is entered and save up is inside red blood cell. Libaweilin is FDA gravid in classificationing with medicine " highest alarm " X level, pregnant woman is banned with, in all animal experiment, sufficient data shows it has the apparent effect that send abnormal and / or embryonic influence.
FDA has serious warning to Libaweilin: This medicine is right fetal have the sex that send abnormal! Although the contact is low,to the cure of 1% dosage also can produce the distinct possibility that causes fetal deformation. Avoid to be pregnant inside 6 months that accordingly Yo age female and its sex spouse are using Libaweilin, should use at least two kinds of reliable contraceptive measure (for instance prophylactic of profess to convinced + safety is covered) . The pulverization that the medical personnel in be pregnant also should avoid to operate Libaweilin for the patient is inspiratory.
Accordingly, the doctor opened Libaweilin, if oneself want to have pregnant or when be pregnant, should explain to the doctor, whether change other remedy; As the doctor, the inquiry answers to have before opening this medicine to the patient without be pregnant reach inform internal affairs of 6 months after using this drug to had made contraceptive step surely, avoid to be pregnant (fasten oversight the spouse of the male patient that plans to want the child and male patient needs to use contraceptive) ; If when using this drug, lactation woman must not not need to stop lactation, galactic also should discard.
■ patient of severe anemia, Mediterranean anaemia, hook cell anaemia does not recommend use Libaweilin. In treating around and cure, answer to monitor haemoglobin often.
■ pancreatitis patient cannot use Libaweilin.
■ have heart medical history or patient of apparent heart disease symptom cannot use Libaweilin. This medicine may bring about the cardiac muscle with deadly heart disease and deadly blame to damage, cardiac muscle stalk is dead. If use profit,Baweilin appears any heart disease are exasperate disease.
■ liver kidney function is unusual person careful with. Flesh anhydride is cleared the patient that leads <50ml/min, do not recommend use Libaweilin. The possibility that this tasting use to produce anaemia in senile patient is more than young patient, function of old people kidney has more drop, bring about save up easily, do not recommend senile patient to use.
■ patient of mobile n/med tuberculosis is unfavorable use Libaweilin.
■ liver ill patient bans oneself immunity with.
■ patient of respiratory tract disease (disease of lung of chronic block sex or asthmatic patient) careful with. Because this medicine can bring about breath difficult, bosom is painful wait, especially when large dose applies. Additional visible rhinitis.
■ when Libaweilin is used at vein drop to note, want to note medicaments chroma and infusion rate. Slow drop notes the vein after specific proposal uses liquid of sodium chloride inject in the manual or dilute of fluid of 5% dextrose inject contains the solution of 1 Mg into every 1 Ml.
Reference material:
■ Chinese doctor association breathes doctor branch, branch of doctor of emergency call of Chinese doctor association. The expert consensus of make a diagnosis and give treatment of common cold standard [J] . Magazine of China internal medicine, 2012, 51 (4) : 330-333. ■ common cold standard uses special multitude medical expert group. Common cold standard uses special multitude expert consensus of medicine [J] . International breathes a magazine, 2015, 35(1):1- 5. ■ Liu Quan, an Shuhua, ai Tao, etc. Chinese children is common consensus of expert of cold standard make a diagnosis and give treatment (2013) . China is practical and paediatrics magazine, 2013, (9):680-686. ■ breath of branch of pedology of China cure society learns group. Children flu is diagnosed with remedial expert consensus (2015 edition) [J] . China is practical and paediatrics clinical records, 2015, 30(17):1296-1303. ■ Chinese doctor association breathes doctor branch. Consensus of expert of grippe of treatment of thing of ill bane of cold of sex of travel of rational application anti-current (2016) [J] . Magazine of China internal medicine, 2016, 55(3):244-248. ■ sanitation of country of People's Republic of China and family planning committee. Plan of guideline of grippe diagnosis and treatment (2018 edition) .2018. Sanitation of country of People's Republic of China and family planning committee government-owned net. ■ China medicine can breathe ill credit to meet " inspiratory therapeutics is breathing pulverization the applied expert consensus in the disease " make expert group. Inspiratory therapeutics is breathing pulverization the applied expert consensus in the disease [J] . China medicine magazine, 2016, 96(34):2696-2708. ■ breath of branch of pedology of China cure society learns group. Children community acquired character is pneumonic administrative manual (2013 edit) (below) [J] . China is paediatrics magazine, 2013, 51(11):856-862. ■ Ge Junbo, xu Yongjian. Internal medicine learns (the 8th edition) . .2013:1 of people sanitation press3-16. ■ Wang Weiping. Pedology. The 8th edition [M] . People sanitation press, 2013:207-209;266-268. ■ Li Lanjuan, ren Gong. Epidemiology. The 8th edition [M] . People sanitation press, 2013:125-130. ■ Yang Baofeng. Pharmacological (the 8th edition) (teaching material of program of level of state of undergraduate course of 925 common higher education) [M] . People sanitation press, 2014:406. ■ national pharmacopoeia is made up appoint meeting. Chinese pharmacopoeia is clinical the notice that use drug (2015 edition) [M] . Chinese medicine press. ■ disease of mouth of brothers of Ministry of Public Health is clinical expert group. Enteroviruses 71 model (case of illness of EV71) infection serious illness is clinical cure expert consensus [J] . China is paediatrics magazine, 2011, 49(9):675-678.
■ Ministry of Public Health of People's Republic of China. Guideline of diagnosis and treatment of brothers mouth disease (2010 edition) [J] . Records of doctor of Chinese practical country, 2012, 19(19):9- 11.
■ Sang Fude. Pyretic - Sang Fude fights microbial cure guideline: The 46th edition [M] . China assist with medical university press, 2016.
■ Ministry of Public Health is reasonable the committee of experts that use drug. The country fights microbial cure guideline (the second edition) [M] . People sanitation press, 2017.
■ collect of Chinese country prescription is made up appoint meeting. Collect of Chinese country prescription, chemical and biological product coil, [M] . People surgeon press, 2010.
■ national provision medicines and chemical reagents supervises administrative total bureau (CFDA) . Medicines and chemical reagents is undesirable reaction Information Circular (the 11st period) . National provision medicines and chemical reagents supervises.http://www.sda.gov.cn/WS01/CL0078/11283.html of net of official of administrative total bureau.
■ Libaweilin is relevant manual of medicines and chemical reagents (homebred) .
■ FDA (American food and medicaments management board) . Libaweilin piece manual: HTtps://www.drugs.com/pro/ribavirin.html
■ FDA. .https://www.drugs.com/pro/rebetol.html of manual of solution of profess to convinced of Ba Weilin of capsule of benefit Ba Weilin, benefit
■ FDA. Manual of fluid of pulverization of benefit Ba Weilin book.https://www.drugs.com/pro/virazole.html.
■ catch a disease of move of China cure society learns branch AIDS group, chinese Medical Association. Guideline of AIDS diagnosis and treatment the 3rd edition (2015 edition) [J] . China is clinical magazine of feeling catch a disease, 2015(5):385-401.
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