vaccinal below the condition that does not know oneself are pregnant what effect does HPV vaccine have?
Author ｜ plain to small red building: Liyuan Xing Fupei is strong
Current, there already was have an inoculation of more than 72 million female on the world HPV is vaccinal. As HPV preventive vaccine is in China each are big of the city gain ground quickly, security became the first issue that broad female cares. And the part is bad media is certain however business chance, vaccinal harmful response exaggerate, take the chance to sow medicinal powder rumor, rich person eyeball.
Our public date ever also undertook refuting a rumor to its: Is HPV vaccine deadly cause damage again? Refuted a rumor!
Consider to make clear through development, HPV vaccine is safe. Before vaccine of 3 kinds of HPV obtains FDA to permit, passed many clinical trial:
9 price of Gradasil 9 are vaccinal: Exceed 15000 females and male
Gradasil4 price is vaccinal: Exceed 29000 females and male
Cervarix is diatomic and vaccinal: Exceed 30000 females
The result of these clinical trials all makes clear: 3 kinds of vaccine are safe and effective. After vaccine appears on the market, FDA still is in monitoring vaccinal crowd to be opposite vaccinal harmful response, since vaccine came out 2006, undesirable incident includes syncope, infrequent allergic reaction to wait. Of course, also case of death of exemple of know exactly about sth, but the prime cause of indemonstrable death is vaccination.
What crowd should undertake HPV vaccinal have an inoculation?
After reading HPV vaccinal guideline, we notice: HPV vaccine does not recommend pregnant woman have an inoculation.
So, a few pregnant woman are vaccinal below the condition that does not know he are pregnant vaccinal, it is especially inside before 3 gravid months, whether can you be opposite fetal influential? Whether can the common deputy response of vaccination accentuate?
NEJM: Pregnant woman vaccination and undesirable and gravid ending have nothing to do
General clinical trial does not accept gravid female to enter group, cannot have experimental research, this is one of research difficulty places. Difficult, seminar is restricted with what the method designs by sample size size. Accordingly, 10 years when appear on the market in HPV vaccine, the security of pregnant woman vaccination remains all the time deliberate.
Till 2017, one is published in " The New England Journal Of Medicine " the article gave out to the security of pregnant woman vaccination eventually the answer. We are with this exemple, show the security of pregnant woman vaccination and effectiveness to everybody.
This research came on October 1, 2006 with Denmark 649389 pregnancy female was example on November 30, 2013, the vaccinal have an inoculation of the group circumstance and connection of information of undesirable and gravid ending are together, analyse its dependency.
■ example is chosen reach classification
After undertaking strict example sieve is checked, defined two groups: The first group includes all what be ending with be being produced alive is gravid, the birth with main analysis of in order to is blemish, slink, low be born weight those who wait is gravid; The 2nd group includes all and gravid, abortion of analysis of in order to and stillborn foetus gravid.
Undertake classified according to revealing time again next: Gravid begin to be used at analysing main birth to the 12nd week blemish; Gravid 7 weeks abort naturally to analysis of 22 weeks of in order to; Gravid 7 Zhou Zhi is born in order to analyses stillborn foetus; Gravid 37 Zhou Qian in order to analyse premature delivery.
■ statistical dependency
(graphic representation: The dependency of gravid vaccination and bad final result is analysed)
If pursue, vaccinal group and not vaccinal group are in basically be born did not distinguish significantly on blemish (there are 65 in 1665 vaccinal groups, 6660 not vaccinal groups have 220; OR, 1.19; 95%CI, 0.90-1.58) ; Natural abortion (in 463 vaccinal groups 20, in 1852 not vaccinal groups 131; OR, 0.71; 95%CI, 0.45-1.14) ; Slink (in 1774 vaccinal groups 116, 7096 not vaccinal groups 407;OR, 1.15.95%CI, 0.93~1.42) ; Low be born weight (in 1768 vaccinal groups 76 in 7072 exemple, not vaccinal groups 277; OR1.10, 95%CI, 0.85~1.43) ; Fetal age is small (in 1768 vaccinal groups 171 in 7072 exemple, not vaccinal groups 783) ; Deadborn (in 501 vaccinal groups 2, in 2004 not vaccinal groups 4; OR, 2.43; 95 ％ CI, 0.45 to 13.21) .
■ conclusion
The female of pregnancy vaccination and photograph of not vaccinal female are compared, the risk that undesirable and gravid ending produces does not have remarkable distinction.
VAERS monitors: Have no fetal and undesirable incident to happen
VAERS is system of report of vaccinal and undesirable incident. Came 2006 from what vaccine appears on the market December 2013, in the report of VAERS, have 147 reports about vaccine of HPV of pregnancy have an inoculation, did not have the happening of fetal and unexpected undesirable incident.
Safety detects still be in proceed, in monitor while, also can provide up to date information to the public. This is undoubtedly those who give the public blindly sth capable of comforting sb.
Although big sample book considers to confirm vaccine of HPV of pregnancy have an inoculation won't increase gravid and bad final result, but as a result of gravid characteristic, still need more evidence to stand firm.
Need to notice:
WHO of World Health Organization and ACOG of association of doctor of American department of gynaecology and obstetrics suggest pregnant woman should avoid vaccinal HPV vaccine at present. So, if have the plan of vaccinal HPV vaccine, should have made contraceptive step. If be in not witting below pregnant circumstance, the accident is vaccinal HPV vaccine also does not need angst or be nervous, for the moment stops have an inoculation can.
Vaccinal have an inoculation is important, it is more important that the sieve is checked
Although at present vaccinal HPV vaccine is heat topic all the time, but a lot of females ignored the sieve besides have an inoculation to examine an issue. Get sth done once and for ever is not after vaccination, want to prevent palace neck cancer, annual and fixed sieve is checked cannot little.
Bibliographical reference:
[1]Scheller N M, pasternak B, m? ? Lgaard-Nielsen D, et Al. Quadrivalent HPV Vaccination And The Risk Of Adverse Pregnancy Outcomes[J] . N Engl J Med, 2017, 376(13):1223-1233.
[2] Cao Zeyi. China department of gynaecology and obstetrics learns [M] . People sanitation press, 2014.
[3] Cheng Lin, zhang Kun, xu Tianmin. Preventive the clinical application progress of HPV vaccine and think [J] . Contemporary tumour medicine, 2017, 25(2):328-331.
[4] Yang Li, wang Jing, ma Cailing. Preventive effectiveness of cancer of neck of palace of HPV vaccine precaution and security Meta are analysed [J] . Magazine of China tumour prevention and cure, 2015, 22(9):719-727.
