Speak of the thymus inside our body, people may understand not much. But a kind of when thymus peptide recovers as the patient such as tumor familiar drug, a lot of people may be not new. It comes from the thymus at the calf, but cell of effective and revulsive immunity, maintain airframe immunity balance, increase disease-resistant capacity.
The consenescence of airframe is accompanying the decline of immune system function. In this process, the decline of thymus function is most apparent.
The consenescence of thymus suffers small environment of nerve endocrine, thymus and cellular wither to die the adjusting control that waits for an element, t cell function, inferior group composition and signal turn guide the access change that produces different rate, cause airframe immunity function finally maladjusted, consequently thymus consenescence is regarded to be in by immunology home one of immunity is the mainest event in anile process.
Accordingly, from proceed with of thymus consenescence angle, study mechanism of anile, immunity, also become a facet with anile the most important immunology.
Come from the enlightenment of naked rat
Look the mice with lovely pretty, always be ineludible the destiny of animal of experiment be regardinged as, more or less does the writer that this invites to belong to mice give birth to some of commiserative heart, think sturdily, mice, regard the Xiaobai of experimental animal as and his like of rat, become known rat especially, having significant contribution to the mankind.
The word says to wait in me after be born before long, go up namely at the beginning of the 60 time of the century, not hairy mice is in England Gelasige the hospital is discovered accidentally, passed a few years again, this kind of mice that comes from mutation of the gene that do not have wool is formally by denominate " naked rat " .
Allow immunology home people glad unceasingly is, this kind of mice not only without wool, still do not have thymus! And at this moment people has understood thymus is important immune organ (the discovery that regards important immunity as the organ about thymus, will introduce at other article) , then, pitiful naked rat people also become a scientist to study the important animal model of immunology mechanism.
Naked rat does not have thymus, because this also does not have cell of T of immune ground troops, immune function is low also must not say. The tumor cell that connects a person can be in this kind not to have thymus grow inside naked mouse system, won't be repelled.
They should grow in aseptic environment normally, even so, its life is far brief still at normal small rat. Brief without thymus life, whether do this mean thymus and consenescence to having affinity?
Thymus and anile relation are announced
China has a lot of idiom that contain philosophy, be like " Things will develop in the opposite direction when they become extreme. " " fill extremely and decline " etc, reflected the pattern of a kind of development of the thing. Namely world everythings on earth, when it development arrives the most brilliant when, process of its be on the wane also began.
People always is ground of assume sth as a matter of course think, decline to often enter senile ability to happen, prove this kind of view is wrong now.
Adolescence is the height of person physiology function, right now the multinomial function of the body is in groove, but the height means decline. After adolescence, the body already was in a kind of function actually the condition of slow decline, because this process progress is slow,be only, people does not have clear sense.
Began what consenescence matures in green development momently then. In the body in all organs, where is this process that function of which the can most acute physiology of reflective human body develops?
Have thymus only. Its development process develops synchronism to spread out with individual life it seems that: It began to degrade slowly since adolescent development maturity.
The ontogenesis characteristic with so peculiar thymus, not be airframe happening, development, by an acute index that fill and declines?
Because thymus is in the significant position in immune system function, people very naturally can think, the beginning of thymus function ebbs, drop what cause immune function stage by stage, whether be program of the airframe consenescence that start begin? Then, anile immune doctrine appeared.
Domestic Walford taught pathology of American California university to offer immune consenescence theory above all 1962. After this had a few important discovery and development to thymus, immunity and anile research.
1977, japanese scientist will be young a transplanting gives the thymus of small rat and medullary cell consenescence small mouse, the antibody that discovers old age small rat as a result generates capacity, it is young and normal to restore the level of small rat; But if undertake thymus alone,transplanting or marrow transplant, do not have apparent effect.
The film " rejuvenescent " stage photo
According to the report, american scientist ever also had done a test. They young the medullary cell of small rat and content of thymus cell extraction inject together is consenescence small rat together. Result discovery, original hair sere, action is logy, old the old age small rat that voice appears in all, become the action color of nimble, hair shines, restored reproductive function even.
Tell namely, young the medullary cell of small rat and fluid of thymus cell extraction make old age small rat appeared actually temporarily " rejuvenescent " phenomenon.
These research explain, adopt immune system " young change " , can defer consenescence. This learned the home to provide fanciful space for old age.
People tentative plan, if be when the person is young a few more draw-out oneself medullary cell is refrigerant the deposit rises, the body after a few years gradually when consenescence, take them again, lose a put oneself in another's position together with thymus element inside, be the arrival that can you delay consenescence?
Medullary cell
Thymus, immunity, anile, 3 person the immanent connection that having profundity certainly. But the specific details that contacts about this kind and effect way, still have very large research space, also become scientists to study one of tasks newly in recent years consequently.
After all, look only from the angle of anile immunology, the author believes, adopt factitious measure, we realize the desire that defers consenescence likely, important still is to continue to announce among them scientific reason.
The person can let mice " rejuvenescent " , also can let oneself realize this dream certainly. Once concern anile theory to study achievement applies successfully at practice, believe everybody has the opportunity that gains long life.
The article represents author point of view only
The picture in article originates network
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