Enzymatic revulsive of alleged liver medicine, it is one kind has the remedy of process of metabolization of the enzymatic active of revulsive liver medicine, metabolization process that accelerates relevant medicaments or human body oneself in fact. Certain pharmaceuticals is OK and revulsive liver is enzymatic increase its active, the chloric aldehyde of natrium of Tuo Ying of the barbitone that be like benzene, benzene, rifampin, hydration category that belongs to liver medicine enzymatic revulsive. Of course, certain pharmaceuticals also can restrain liver enzymatic abate its are active, if chloromycetin, isoniazid is mixed,wait to amino salicylic acid.
One, liver medicine enzymatic revulsive
Revulsive or the medicaments that quickens enzymatic active of liver ministry medicaments, enzymatic revulsive of medicine of the liver that be called. Certain pharmaceuticals is OK and revulsive liver is enzymatic increase its active, certain pharmaceuticals also can restrain liver enzymatic abate its are active. When liver medicine enzymatic revulsive or depressor and when be being used jointly by the medicaments of enzymatic metabolization, these medicaments can affect the metabolization of other remedy, change their cleared rate and specific action result.
2, common liver medicine enzymatic revulsive
1, CYP1A2 revulsive
Enzymatic revulsive is like a lot of liver medicaments barbitone of benzene Tuo Ying, benzene but revulsive CYP1A2, quicken the metabolization of CYP1A2 heart thing, reduce heart thing effect, make its cannot reach effective haemal medicaments consistency even. In addition, smoking can increase the active of hepatic particle on certain level. Consider to discover, the coffeine purify rate inside body of the person that smoke compares normal person tower above 56% above.
2, CY2C9 revulsive
CYP2C9 revulsive is main give priority to in order to block the medicaments such as Ma Xiping, barbiturate. Meanwhile, alcohol also is one of lead content of CY2C9. When taking CYP2C9 metabolization medicaments, the patient answers abstinence.
3, CYP3A4 revulsive
CYP3A4 revulsive basically is rifampin, compare at element of mildew of congeneric benefit blessing kind the flummery of blessing of benefit of Dingji of benefit blessing gush of antibiotic, rifampin is stronger to P450 revulsive action, can consider to use flummery of blessing of benefit of Dingji of benefit blessing gush to replace rifampin to treat below special situation. Research makes clear, the circumstance that element of peaceful benefit mildew and chroma of element of lubricious mildew of the serum when CYP3A4 revulsive is used jointly can appear to be reduced significantly, this kind of circumstance causes failure of the cure that fight bacterium very easily.
The addition of liver medicine enzymatic active changed medicaments metabolization, go up in certain level but machine make the body response to medicaments produces different reaction. If use benzene barbitone continuously, make airframe produces pair of benzene barbitone not only be able to bear or endure suffer a gender, and the curative effect that can reduce other remedy. To a lot of wide chart medicaments, their side-effect not only numerous and duration is relatively longer, liver medicine enzymatic depressor and this kind of medicaments is collective action, the side-effect effect to human body can be reduced on utmost, make airframe returns to normal as soon as possible.
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