Yesterday, be aimed at once resounding and whole learning encircles " Han Chunyu incident " , net of official of university of Heibei science and technology releases newest findings, call this school associate professor Han Chunyu the controversy paper before is here medium nonexistent " subjective make a holiday " , and should contend for argumentative writing had had the base that publishs afresh no longer.
Now morning, han Chunyu also investigates processing to make known his position as a result through learning to proofread this, say: "The technology edits to research a field in the gene of international forward position, put in a lot of unpredictable problems. In experienced doubt, after removing draft and investigation, the guidance that passes expert of person of the same trade of school inside and outside and farther experimental test and verify, realise deeply, process of the blemish of experimental design existence of the paper that remove draft, research is occurring not precise issue, the published scholar of domestic and international person of the same trade to cause misdirect and manpower material resources waste of the paper. After the paper is published, face the doubt of media and person of the same trade, fail sober reason is treated, published a few undeserved opinion on public affairs, brought needless confusion to social community. " in statement, han Chunyu expressed regret, conveyed acknowledgment to the attention of scholar of person of the same trade and society.
According to this announcement, university of Heibei science and technology established board of inquiry in the light of this matter, act on " depend on compasses, rigorous standard, be practical and realistic, objective justice lawfully " principle, checked the data of all and primitive test that this paper involves seriously, entrust key laboratory of tripartite state to begin repeat test of test and verify, according to learning, administration two lines undertook be checkinged in the round.
Announcement shows, after this paper is published, pay of individual housing of Han Chunyu, title, pay all did not produce change. In investigating a process, award of the scientific research project that Han Chunyu asks go back is based on institute of the paper that remove draft to obtain actively, performance, honorary title, society holds a post etc. Concerned respect already cancelled the honorary title that Han Chunyu wins according to the regulation, the scientific research project that ended group of Han rain during springtime to assume called in scientific research funds, called in place of group of Han rain during springtime wins award of performance of school scientific research. Individual society holds a post to be being dealt with by legal process.
Time returns about 2 years half before, han Chunyu is as the name of newsletter writer at that time " DNA-guided Genome Editing Using The Natronobacterium GregoryiArgonaute " paper by " natural " of the magazine child print " Nature Biotechnology " print hair. Rain during springtime of paper Sino-South Korean puts forward, this plants NgAgo enzymatic can clipping resembles scissors such DNA alignment in order to modify gene group. And a few years ago, scientific group just just begins to use another kind enzymatic -- Cas9 -- come series of cut gene series, such operation is theoretic OK identifying the gene that cause cancer is applied to even " design " baby.
Han Chunyu claims in his research, ngAgo is mixed more effectively than Cas9 accurate. This research justs to be published, in China whole society and foreign learning circle caused huge echo. Regard this as the leader of the project, han Chunyu is known as China very quickly also " scientific giant star " . The view thinks even, he may become gainer of a nobel prize.
NgAgo-gDNA system: NgAgo is alkaline bacili of salt of be addicted to of family name of a kind of case (Natronobacterium Gregoryi) medium Argonaute albumen, it can use as cut inside nucleic acid enzymatic, in guide DNA (Guide DNA, GDNA) guide below, undertake in person cell gene group edits. Cas9-sgRNA system: Cas is the abbreviation of CRISPR relevant albumen, when applying actually, people can regard two kinds of guide as RNA TracrRNA and CrRNA (GRNA) shirt-sleeve perhaps form only guide RNA together (Single Guide RNA, sgRNA) , be used to guide enzymatic Cas9 to combine target DNA alignment to go up to have cut, among them Cas9 and SgRNA are called Cas9-sgRNA system together.Will simply look, han Chunyu studies because of this achievement becomes the biologist with the hottest 2016 bound of Chinese scientific research, the reason has 2: Above all, this positive result is right at present the CRISPR-CAS9 technology of in full swing posed a challenge. The NgAgo-gDNA system photograph of his original creation has at showing relatively Cas9-sgRNA system, in carried cut efficiency while, have vaster applied potential and smaller target alignment restriction, ; Next, he serves as " the blame that is not famous university is famous associate professor " , completed circle of this scientific research beautifully " counterattack " .
But, scientific group had doubt reputation very quickly, and cannot be repeated by more and more groups as the experiment, han Chunyu and his this science gain faces be between the beetle and the block trustful crisis for a time.
The biggest doubt is centered in specific unit process of cargo bandling, the experimental method of the paper did not bring the gene in the cell editorial efficient result: Somebody puts forward gene group of Han Chunyu to edit a result to cannot repeat, someone says to be able to repeat but efficiency is low, each other have final conclusion vexedly, hard.
And two months after paper of the rain during springtime that be apart from Han is published, stranger thing happened. Student of Australian state-maintaineding college builds Tan Buer anxious (Gaetan Burgio) says to be able to repeat this test result before this, but on July 29, he sends long article to oppugn NgAgo result, although he is mixed,say to worked in the same place to make an attempt for many times in a month in the past, but final discovery, ngAgo cannot undertake gene group edits.
He says: "Meanwhile, congress of my Twitter account from me, TAGC, E-mail, Google discussion group the discovery in discussing for many times, individual plant, small to human cell rat or zebra fish have the experimental move that a lot of people are trying to use Han Chunyu gene group edits, but the DNA that is use NgAgo no matter, MRNA is protein still, they fail to detect gene group edits " . Because of this, he appeals " Nature Biotechnology " the magazine intervenes, ask Han Chunyu publishs primitive data.
This open letter, pay close attention to and discuss what caused relevant domain scientist instantly. International turns gene technology association (ISTT) is pushed on its Twitter sent Boer the real name of anxious article and digital scientist is commented on. Many scientist thinks, " Nature Biotechnology " the magazine ought to ask Han Chunyu makes public primitive data and particular test condition. The doubt of whole episode can say to reach a new climax here, and be global limits inside.
The report of concerned this matter emerges in endlessly all the time, respect of Dan Hanchun rain does not have the front to respond to inside very long period of time. Meanwhile, han Chunyu suffers those who invite China is top and efficient address, obtained multinomial and special award and allowance. The honor that besides still all sorts of coming from organize and projects of a few large national scientific research: Han Chunyu is elected as Heibei division assist vice-chairman, the school is selected also " double top-ranking " , obtain 200 million investment; The Party committee of university of Heibei science and technology also awards him 54 youths medal, this is the 14 highest honor to 40 years old of youths, and Han Chunyu at that time already 42 years old.
Arrived in August 2017, still be in in everybody what is be the truth after all and when arguing, respect of Han rain during springtime removed relevant paper and patent early or late. Net of official of university of Heibei science and technology also releases statement to say, already decided to start pair of Han Chunyu this academic appraise sth through discussion that studies positive result and relevant program. Such " retreat in order to advance " let this matter be in next public eye shot was exited cloudily inside period of time.
Till August 31, 2018, we just saw the result moving of this incident states finally.
Review this scientific event that has neared end, han Chunyu from " blame mainstream university " anonymous generation, hold a month in both hands to numerous star " gainer of award of Chinese next Nuo " , arrive again removing draft is to be considered as even " academic cheater " , fumble with finally " blame is subjective make a holiday " ending, its are having the caution interest that merits our everybody to think in great quantities rear.
On scientific research, what once rely on time to go merely,prove some thing is right with the fault, hard to avoid can take the pity that after the event is made up for hard. Indeed, any scientific discovery ought to very rigorous. Be in especially biology medicine domain, this may matter to future to delay a series of extended application and clinical practice by former hair technology. Accordingly, no matter be of experimental data but repeatability or technicality, answer withstand relapses deliberate. This asks the researcher can bear a responsibility to his conclusion, the experimental result much point of view that makes to place before the paper is published seeks testimony, and ought not to be to be in the detail that encounters the oversight since after-thought of the ability when cannot repeating experimental result.
Additional, the paper that any print deliver is adopted through examine and verify of system of appraise sth through discussion of person of the same trade. Although system of examine and verify costs bad news force, but still put in malpractice, bring about such the happening of second incident. A few scholars think to ought to establish a tripartite to organize, publish process of paper appraise sth through discussion, change technological process it is the person of the same trade after publishing to evaluate. The PubPeer of American California is the pioneer of this respect. But the new technological process of PubPeer also caused new issue to discuss. Can foreknow in future inside period of time, after all what kind of go over a manuscript or draft flow still just needs more scientificly to discuss for a long time.
And in scientific discovery radiation comes in the process of whole society, public opinion transmission also is an indispensable link, face this kind to still be in " swaddle period " , the burgeoning technology that detects without preliminary practice, expect at the beginning probably or gift its it is so important to cross the story of soul-stirring and be done not have too, also do not have so necessary.
