Compile: The month issues lotus
Cancer of rectum of move sex knot (MCRC) when second line above is treated, the situation that clinical doctor often faces is patient condition very good, but already was in condition of a few practicable that do not have medicine, accordingly platinum of Ao Sha benefit introduces again not scarce in cure of MCRC later period, also can obtain certain curative effect really, but the mortality immunity that after rare person understands this medicine to introduce again, causes is revulsive and integrated ask for (OIIS) . Professor Mauri of Italy was made to this respect content on Ann Oncol magazine elaborate, hope to be helped somewhat to clinical work.
OIIS is a kind scarce but can high potentially the deputy reaction of coerce life, the plaque that its feature is acute fit decreases, anaemia of sex of exhaustion of result of calorific, kidney, hemolysis, shiver, hind backache and haemorrhage, the symptom happens within 24 hours after benefit platinum applies Ao Sha, 4 patients of the report in existing document all are deadly sex. OIIS and platinum of benefit of long-term application Ao Sha are concerned, happen at more average when 16 cycle contain platinic program of Ao Sha benefit to treat, notable is OIIS what happen when out of service introduces again after Ao Sha benefit is platinic is earlier, when happening on average at platinum of Ao Sha benefit to introduce 4 period of treatment again.
The potential mechanism of OIIS is not clear, think the generation of medicaments particularity antibody is likely at present to it relevant, the near future discovers OIIS and the antibody of many medicaments dependence are concerned, these antibody are right a few kinds of compound all sensitive, the other that uses after pair of potential Ao Sha benefit are platinic fights tumor to treat a likelihood to also can produce an effect, what affect cure then is successional.
Anyhow, when introducing platinum of Ao Sha benefit again, need to note OIIS risk, although scarce, come on hide, but may be deadly sex however, and the cure that disturbs sequel possibly still.
Bibliographical reference
Https://www.ncbi.nlm.nih.gov/pubmed/30060112
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